ENSFHEP00000019769 protein (Fundulus heteroclitus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

ENSFHEP00000019769

Ig-like domain-containing protein. (184 aa)

Predicted Functional Partners:

ENSFHEP00000004357

0.921

ENSFHEP00000028442

0.921

ENSFHEP00000005309

0.698

ENSFHEP00000005371

0.698

pold2

0.680

pold1

0.653

mus81

0.627

LOC105926863

0.627

snrpe

0.588

ENSFHEP00000020981

0.578

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000004357	ENSFHEP00000019769	ENSFHEP00000004357	ENSFHEP00000019769	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.921
ENSFHEP00000005309	ENSFHEP00000005371	ENSFHEP00000005309	ENSFHEP00000005371	Uncharacterized protein.	Uncharacterized protein.	0.999
ENSFHEP00000005309	ENSFHEP00000019769	ENSFHEP00000005309	ENSFHEP00000019769	Uncharacterized protein.	Ig-like domain-containing protein.	0.698
ENSFHEP00000005309	mus81	ENSFHEP00000005309	ENSFHEP00000001971	Uncharacterized protein.	MUS81 structure-specific endonuclease subunit.	0.999
ENSFHEP00000005309	pold1	ENSFHEP00000005309	ENSFHEP00000033611	Uncharacterized protein.	DNA polymerase.	0.917
ENSFHEP00000005371	ENSFHEP00000005309	ENSFHEP00000005371	ENSFHEP00000005309	Uncharacterized protein.	Uncharacterized protein.	0.999
ENSFHEP00000005371	ENSFHEP00000019769	ENSFHEP00000005371	ENSFHEP00000019769	Uncharacterized protein.	Ig-like domain-containing protein.	0.698
ENSFHEP00000005371	mus81	ENSFHEP00000005371	ENSFHEP00000001971	Uncharacterized protein.	MUS81 structure-specific endonuclease subunit.	0.999
ENSFHEP00000005371	pold1	ENSFHEP00000005371	ENSFHEP00000033611	Uncharacterized protein.	DNA polymerase.	0.917
ENSFHEP00000019769	ENSFHEP00000004357	ENSFHEP00000019769	ENSFHEP00000004357	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.921
ENSFHEP00000019769	ENSFHEP00000005309	ENSFHEP00000019769	ENSFHEP00000005309	Ig-like domain-containing protein.	Uncharacterized protein.	0.698
ENSFHEP00000019769	ENSFHEP00000005371	ENSFHEP00000019769	ENSFHEP00000005371	Ig-like domain-containing protein.	Uncharacterized protein.	0.698
ENSFHEP00000019769	ENSFHEP00000020981	ENSFHEP00000019769	ENSFHEP00000020981	Ig-like domain-containing protein.	TROVE domain-containing protein.	0.578
ENSFHEP00000019769	ENSFHEP00000028442	ENSFHEP00000019769	ENSFHEP00000028442	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.921
ENSFHEP00000019769	LOC105926863	ENSFHEP00000019769	ENSFHEP00000032171	Ig-like domain-containing protein.	Survival of motor neuron 1, telomeric.	0.627
ENSFHEP00000019769	mus81	ENSFHEP00000019769	ENSFHEP00000001971	Ig-like domain-containing protein.	MUS81 structure-specific endonuclease subunit.	0.627
ENSFHEP00000019769	pold1	ENSFHEP00000019769	ENSFHEP00000033611	Ig-like domain-containing protein.	DNA polymerase.	0.653
ENSFHEP00000019769	pold2	ENSFHEP00000019769	ENSFHEP00000026696	Ig-like domain-containing protein.	Polymerase (DNA directed), delta 2, regulatory subunit.	0.680
ENSFHEP00000019769	snrpe	ENSFHEP00000019769	ENSFHEP00000032931	Ig-like domain-containing protein.	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	0.588
ENSFHEP00000020981	ENSFHEP00000019769	ENSFHEP00000020981	ENSFHEP00000019769	TROVE domain-containing protein.	Ig-like domain-containing protein.	0.578

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

15

PPI enrichment p-value:

1.11e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000387

Spliceosomal snRNP assembly

4 of 18

2.5

2.89

3.42e-06

GO:0000398

mRNA splicing, via spliceosome

5 of 139

1.71

1.89

4.80e-05

GO:0065003

Protein-containing complex assembly

5 of 356

1.3

1.17

0.00066

GO:0090304

Nucleic acid metabolic process

8 of 1212

0.98

0.94

0.00010

GO:0016070

RNA metabolic process

6 of 893

0.98

0.77

0.0025

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

6 of 616

1.15

0.97

0.0012

GO:0003676

Nucleic acid binding

9 of 1431

0.96

0.95

3.21e-05

GO:0003887

DNA-directed DNA polymerase activity

2 of 18

2.2

0.85

0.0273

GO:0004536

Deoxyribonuclease activity

2 of 23

2.1

0.78

0.0359

GO:0140097

Catalytic activity, acting on DNA

3 of 153

1.45

0.69

0.0359

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005682

U5 snRNP

4 of 13

2.65

3.51

2.56e-07

GO:0005685

U1 snRNP

4 of 16

2.56

3.47

2.56e-07

GO:0071004

U2-type prespliceosome

4 of 26

2.34

3.14

7.32e-07

GO:0046540

U4/U6 x U5 tri-snRNP complex

4 of 27

2.33

3.13

7.32e-07

GO:0120114

Sm-like protein family complex

5 of 62

2.06

3.1

2.56e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8719

U4 snRNP

4 of 5

3.06

4.06

3.66e-08

CL:8712

Spliceosomal snRNP complex

5 of 34

2.32

3.72

3.67e-08

CL:9508

DNA polymerase complex

2 of 12

2.38

1.19

0.0065

CL:9440

Catalytic activity, acting on DNA, and Polymerase switching

3 of 114

1.58

0.96

0.0095

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

5 of 173

1.62

1.98

1.14e-05

map03420

Nucleotide excision repair

3 of 68

1.8

1.43

0.0011

map03410

Base excision repair

2 of 44

1.82

0.85

0.0228

map03440

Homologous recombination

2 of 55

1.72

0.8

0.0263

map03430

Mismatch repair

2 of 56

1.71

0.8

0.0263

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-77588

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

2 of 6

2.68

1.39

0.0029

MAP-111367

SLBP independent Processing of Histone Pre-mRNAs

2 of 6

2.68

1.39

0.0029

MAP-72163

mRNA Splicing - Major Pathway

4 of 123

1.67

1.35

0.0012

MAP-72172

mRNA Splicing

4 of 135

1.63

1.33

0.0012

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

4 of 223

1.41

1.07

0.0029

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005687

U4 snRNP

2 of 4

2.86

1.34

0.0038

GOCC:0034719

SMN-Sm protein complex

2 of 5

2.76

1.33

0.0038

GOCC:0043625

Delta DNA polymerase complex

2 of 7

2.61

1.31

0.0040

GOCC:0120114

Sm-like protein family complex

3 of 43

2.0

1.25

0.0038

GOCC:0000228

Nuclear chromosome

3 of 174

1.39

0.78

0.0195

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0508

mRNA splicing

4 of 14

2.61

3.71

9.40e-08

KW-0539

Nucleus

6 of 349

1.39

1.75

4.19e-06

KW-0687

Ribonucleoprotein

4 of 133

1.64

1.71

0.00010

KW-0747

Spliceosome

2 of 8

2.56

1.64

0.00096

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001163

Sm domain, eukaryotic/archaea-type

4 of 16

2.56

3.04

1.86e-06

IPR047575

Sm domain

4 of 17

2.53

3.03

1.86e-06

IPR010920

LSM domain superfamily

4 of 19

2.48

3.01

1.86e-06

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00651

snRNP Sm proteins

4 of 15

2.58

3.58

1.62e-07

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