LOC105920159 protein (Fundulus heteroclitus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC105920159

Protocadherin 2 alpha c. (1003 aa)

Predicted Functional Partners:

fjx1

0.505

fat1

0.452

fat2

0.452

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC105920159	fat1	ENSFHEP00000025072	ENSFHEP00000014401	Protocadherin 2 alpha c.	FAT atypical cadherin 1a.	0.452
LOC105920159	fat2	ENSFHEP00000025072	ENSFHEP00000029423	Protocadherin 2 alpha c.	FAT atypical cadherin 2.	0.452
LOC105920159	fjx1	ENSFHEP00000025072	ENSFHEP00000026842	Protocadherin 2 alpha c.	Four-jointed box protein 1.	0.505
fat1	LOC105920159	ENSFHEP00000014401	ENSFHEP00000025072	FAT atypical cadherin 1a.	Protocadherin 2 alpha c.	0.452
fat1	fjx1	ENSFHEP00000014401	ENSFHEP00000026842	FAT atypical cadherin 1a.	Four-jointed box protein 1.	0.908
fat2	LOC105920159	ENSFHEP00000029423	ENSFHEP00000025072	FAT atypical cadherin 2.	Protocadherin 2 alpha c.	0.452
fat2	fjx1	ENSFHEP00000029423	ENSFHEP00000026842	FAT atypical cadherin 2.	Four-jointed box protein 1.	0.908
fjx1	LOC105920159	ENSFHEP00000026842	ENSFHEP00000025072	Four-jointed box protein 1.	Protocadherin 2 alpha c.	0.505
fjx1	fat1	ENSFHEP00000026842	ENSFHEP00000014401	Four-jointed box protein 1.	FAT atypical cadherin 1a.	0.908
fjx1	fat2	ENSFHEP00000026842	ENSFHEP00000029423	Four-jointed box protein 1.	FAT atypical cadherin 2.	0.908

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

54

PPI enrichment p-value:

0.095

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

7 of 174

1.39

1.77

3.35e-06

GO:0000160

Phosphorelay signal transduction system

6 of 154

1.38

1.59

2.11e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016772

Transferase activity, transferring phosphorus-containing groups

6 of 307

1.08

0.85

0.0025

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2736

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and HPT domain superfamily

9 of 62

1.95

5.23

4.43e-15

CL:2723

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and HPT domain superfamily

10 of 85

1.86

5.03

5.10e-16

CL:2741

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and HPT domain superfamily

8 of 56

1.94

4.71

4.34e-13

CL:2747

PAS-associated, C-terminal, and HPT domain superfamily

7 of 40

2.03

4.59

9.94e-12

CL:2702

Signal transduction histidine kinase-related protein, C-terminal, and Signaling

11 of 135

1.7

4.25

4.99e-16

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

7 of 522

0.91

0.79

0.00059

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030428

Cell septum

3 of 11

2.22

1.83

0.00032

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

9 of 182

1.48

2.67

1.11e-10

KW-0418

Kinase

5 of 232

1.12

0.9

0.0021

KW-0902

Two-component regulatory system

2 of 19

1.81

0.75

0.0355

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001789

Signal transduction response regulator, receiver domain

9 of 174

1.5

2.63

6.23e-10

IPR011006

CheY-like superfamily

9 of 175

1.5

2.62

6.23e-10

IPR036641

HPT domain superfamily

3 of 7

2.42

2.11

0.00011

IPR003660

HAMP domain

3 of 17

2.03

1.62

0.00065

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

5 of 88

1.54

1.61

0.00011

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00448

cheY-homologous receiver domain

9 of 173

1.5

2.79

4.42e-11

SM00304

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain

3 of 18

2.01

1.91

0.00014

SM00388

His Kinase A (phosphoacceptor) domain

5 of 92

1.52

1.82

1.60e-05

SM00387

Histidine kinase-like ATPases

5 of 131

1.37

1.48

5.79e-05

SM00073

Histidine Phosphotransfer domain

2 of 6

2.31

1.47

0.0018

(more ...)

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