LOC105919473 protein (Fundulus heteroclitus)

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

LOC105919473

ATPase family AAA domain containing 1a; Belongs to the AAA ATPase family. (381 aa)

Predicted Functional Partners:

ubxn7

0.976

ufd1

0.833

pex19

0.797

ubxn1

0.793

chmp3

0.789

pex13

0.786

pex12

0.785

yod1

0.781

faap100

0.775

nploc4

0.775

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC105919473	chmp3	ENSFHEP00000026210	ENSFHEP00000026421	ATPase family AAA domain containing 1a; Belongs to the AAA ATPase family.	Charged multivesicular body protein 3.	0.789
LOC105919473	faap100	ENSFHEP00000026210	ENSFHEP00000005774	ATPase family AAA domain containing 1a; Belongs to the AAA ATPase family.	Si:dkey-57h18.1.	0.775
LOC105919473	nploc4	ENSFHEP00000026210	ENSFHEP00000011825	ATPase family AAA domain containing 1a; Belongs to the AAA ATPase family.	NPL4 homolog, ubiquitin recognition factor.	0.775
LOC105919473	pex12	ENSFHEP00000026210	ENSFHEP00000026540	ATPase family AAA domain containing 1a; Belongs to the AAA ATPase family.	Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family.	0.785
LOC105919473	pex13	ENSFHEP00000026210	ENSFHEP00000032546	ATPase family AAA domain containing 1a; Belongs to the AAA ATPase family.	Peroxisomal biogenesis factor 13.	0.786
LOC105919473	pex19	ENSFHEP00000026210	ENSFHEP00000023552	ATPase family AAA domain containing 1a; Belongs to the AAA ATPase family.	Peroxisomal biogenesis factor 19.	0.797
LOC105919473	ubxn1	ENSFHEP00000026210	ENSFHEP00000022365	ATPase family AAA domain containing 1a; Belongs to the AAA ATPase family.	UBX domain protein 1.	0.793
LOC105919473	ubxn7	ENSFHEP00000026210	ENSFHEP00000034828	ATPase family AAA domain containing 1a; Belongs to the AAA ATPase family.	UBX domain protein 7.	0.976
LOC105919473	ufd1	ENSFHEP00000026210	ENSFHEP00000016571	ATPase family AAA domain containing 1a; Belongs to the AAA ATPase family.	Ubiquitin recognition factor in ER associated degradation 1.	0.833
LOC105919473	yod1	ENSFHEP00000026210	ENSFHEP00000011498	ATPase family AAA domain containing 1a; Belongs to the AAA ATPase family.	YOD1 deubiquitinase.	0.781
chmp3	LOC105919473	ENSFHEP00000026421	ENSFHEP00000026210	Charged multivesicular body protein 3.	ATPase family AAA domain containing 1a; Belongs to the AAA ATPase family.	0.789
faap100	LOC105919473	ENSFHEP00000005774	ENSFHEP00000026210	Si:dkey-57h18.1.	ATPase family AAA domain containing 1a; Belongs to the AAA ATPase family.	0.775
faap100	ubxn1	ENSFHEP00000005774	ENSFHEP00000022365	Si:dkey-57h18.1.	UBX domain protein 1.	0.516
faap100	ubxn7	ENSFHEP00000005774	ENSFHEP00000034828	Si:dkey-57h18.1.	UBX domain protein 7.	0.999
faap100	ufd1	ENSFHEP00000005774	ENSFHEP00000016571	Si:dkey-57h18.1.	Ubiquitin recognition factor in ER associated degradation 1.	0.991
faap100	yod1	ENSFHEP00000005774	ENSFHEP00000011498	Si:dkey-57h18.1.	YOD1 deubiquitinase.	0.958
nploc4	LOC105919473	ENSFHEP00000011825	ENSFHEP00000026210	NPL4 homolog, ubiquitin recognition factor.	ATPase family AAA domain containing 1a; Belongs to the AAA ATPase family.	0.775
nploc4	ubxn1	ENSFHEP00000011825	ENSFHEP00000022365	NPL4 homolog, ubiquitin recognition factor.	UBX domain protein 1.	0.516
nploc4	ubxn7	ENSFHEP00000011825	ENSFHEP00000034828	NPL4 homolog, ubiquitin recognition factor.	UBX domain protein 7.	0.999
nploc4	ufd1	ENSFHEP00000011825	ENSFHEP00000016571	NPL4 homolog, ubiquitin recognition factor.	Ubiquitin recognition factor in ER associated degradation 1.	0.998

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.845

expected number of edges:

10

PPI enrichment p-value:

0.000782

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007264

Small GTPase mediated signal transduction

6 of 207

1.64

1.94

2.04e-05

GO:0007265

Ras protein signal transduction

5 of 152

1.69

1.74

0.00012

GO:0035556

Intracellular signal transduction

9 of 1154

1.07

1.13

2.04e-05

GO:0071803

Positive regulation of podosome assembly

2 of 9

2.52

0.86

0.0270

GO:1902117

Positive regulation of organelle assembly

3 of 72

1.8

0.85

0.0226

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070290

N-acylphosphatidylethanolamine-specific phospholipase D activity

2 of 3

3.0

1.07

0.0119

GO:0004630

Phospholipase D activity

2 of 3

3.0

1.07

0.0119

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000145

Exocyst

2 of 16

2.27

0.72

0.0472

GO:0071944

Cell periphery

10 of 4170

0.56

0.39

0.0137

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:12878

Mixed, incl. Rho (Ras homology) subfamily of Ras-like small GTPases, and RHOU GTPase cycle

4 of 38

2.2

2.23

4.34e-05

CL:12871

Mixed, incl. Small GTPase mediated signal transduction, and RHO GTPases Activate WASPs and WAVEs

5 of 193

1.59

1.67

0.00010

CL:11806

Phospholipase D. Active site motifs.

2 of 5

2.78

1.33

0.0039

CL:20320

Exocyst

2 of 6

2.7

1.28

0.0046

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04014

Ras signaling pathway

10 of 225

1.83

4.82

1.04e-15

map05212

Pancreatic cancer

6 of 75

2.08

4.05

9.00e-10

map04072

Phospholipase D signaling pathway

5 of 154

1.69

2.25

2.96e-06

map05210

Colorectal cancer

4 of 89

1.83

2.13

2.09e-05

map05231

Choline metabolism in cancer

4 of 99

1.78

2.05

2.63e-05

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0004012

ROS cell

2 of 2

3.18

1.28

0.0049

BTO:0003432

EL-4 cell

2 of 2

3.18

1.28

0.0049

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098981

Cholinergic synapse

2 of 5

2.78

1.0

0.0152

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00229

Guanine nucleotide exchange factor for Ras-like GTPases

3 of 18

2.4

1.95

0.00022

SM00147

Guanine nucleotide exchange factor for Ras-like small GTPases

3 of 25

2.26

1.87

0.00027

SM00314

Ras association (RalGDS/AF-6) domain

3 of 28

2.21

1.86

0.00027

SM00155

Phospholipase D. Active site motifs.

2 of 5

2.78

1.54

0.0016

SM00312

PhoX homologous domain, present in p47phox and p40phox.

2 of 34

1.95

0.75

0.0386

(more ...)

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