STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC105938437Carboxypeptidase B1 (tissue). (382 aa)    
Predicted Functional Partners:
f2
Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.
   
 0.821
ENSFHEP00000006626
Uncharacterized protein.
   
 0.697
agt
Angiotensinogen; Belongs to the serpin family.
   
 
  0.588
sgpl1
Sphingosine-1-phosphate lyase 1.
      
 0.517
plpp2
Lipid phosphate phosphohydrolase 2.
     
 0.515
plg
Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]
   
 
 0.510
LOC105926862
Elastase 3 like; Belongs to the peptidase S1 family.
   
 
 0.493
LOC105921085
Zgc:112160; Belongs to the peptidase S1 family.
   
 
 0.491
cpn1
Carboxypeptidase N, polypeptide 1.
   
 
 0.486
LOC105939654
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
   
 
 0.481
Your Current Organism:
Fundulus heteroclitus
NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.