STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lgals8Galectin. (314 aa)    
Predicted Functional Partners:
calcoco2
Calcium binding and coiled-coil domain 2.
    
 
 0.848
ttc13
Tetratricopeptide repeat domain 13.
    
 
 0.551
ENSFHEP00000006667
RBR-type E3 ubiquitin transferase.
      
 0.515
ubr7
Ubiquitin protein ligase E3 component n-recognin 7.
      
 0.515
TRIM67
Tripartite motif containing 67.
      
 0.515
rnf217
RBR-type E3 ubiquitin transferase.
      
 0.512
ENSFHEP00000013606
Tax1 (human T-cell leukemia virus type I) binding protein 1b.
   
 
 0.509
rnf8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
      
 0.495
LOC105934315
Tax1 (human T-cell leukemia virus type I) binding protein 1a.
   
 
 0.444
Your Current Organism:
Fundulus heteroclitus
NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog
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