STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tirapToll-interleukin 1 receptor (TIR) domain containing adaptor protein. (274 aa)    
Predicted Functional Partners:
traf6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.992
irak4
Interleukin-1 receptor-associated kinase 4.
    
 0.988
myd88
MYD88 innate immune signal transduction adaptor.
    
 0.984
ENSFHEP00000015299
TIR domain-containing protein; Belongs to the Toll-like receptor family.
   
 0.982
LOC105917580
TIR domain-containing protein.
   
 0.976
LOC105919258
Interleukin-1 receptor-associated kinase 1.
   
 0.973
LOC105936620
Toll-like receptor 18.
   
 0.972
tollip
Toll interacting protein.
     
 0.969
LOC105923990
Uncharacterized protein.
   
 0.951
LOC105917579
TIR domain-containing protein.
   
 0.951
Your Current Organism:
Fundulus heteroclitus
NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.