cop1 protein (Fundulus heteroclitus) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

cop1

COP1 E3 ubiquitin ligase. (695 aa)

Predicted Functional Partners:

det1

0.995

ddb2

0.973

ddb1

0.960

ercc8

0.946

LOC105934647

0.932

rbx1

0.875

LOC105939250

0.860

LOC105921876

0.853

stk40

0.841

LOC105933792

0.834

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC105921876	cop1	ENSFHEP00000000974	ENSFHEP00000031346	Ets variant 5a.	COP1 E3 ubiquitin ligase.	0.853
LOC105921876	det1	ENSFHEP00000000974	ENSFHEP00000023566	Ets variant 5a.	DET1 partner of COP1 E3 ubiquitin ligase.	0.744
LOC105921876	stk40	ENSFHEP00000000974	ENSFHEP00000000277	Ets variant 5a.	Serine/threonine-protein kinase 40.	0.788
LOC105933792	LOC105934647	ENSFHEP00000008575	ENSFHEP00000001063	Cullin 4A; Belongs to the cullin family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.404
LOC105933792	cop1	ENSFHEP00000008575	ENSFHEP00000031346	Cullin 4A; Belongs to the cullin family.	COP1 E3 ubiquitin ligase.	0.834
LOC105933792	ddb1	ENSFHEP00000008575	ENSFHEP00000034388	Cullin 4A; Belongs to the cullin family.	Damage-specific DNA binding protein 1.	0.992
LOC105933792	ddb2	ENSFHEP00000008575	ENSFHEP00000019395	Cullin 4A; Belongs to the cullin family.	Damage-specific DNA binding protein 2.	0.959
LOC105933792	det1	ENSFHEP00000008575	ENSFHEP00000023566	Cullin 4A; Belongs to the cullin family.	DET1 partner of COP1 E3 ubiquitin ligase.	0.877
LOC105933792	ercc8	ENSFHEP00000008575	ENSFHEP00000015379	Cullin 4A; Belongs to the cullin family.	Excision repair cross-complementation group 8.	0.977
LOC105933792	rbx1	ENSFHEP00000008575	ENSFHEP00000033508	Cullin 4A; Belongs to the cullin family.	Ring-box 1, E3 ubiquitin protein ligase.	0.982
LOC105934647	LOC105933792	ENSFHEP00000001063	ENSFHEP00000008575	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Cullin 4A; Belongs to the cullin family.	0.404
LOC105934647	cop1	ENSFHEP00000001063	ENSFHEP00000031346	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	COP1 E3 ubiquitin ligase.	0.932
LOC105934647	ddb2	ENSFHEP00000001063	ENSFHEP00000019395	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Damage-specific DNA binding protein 2.	0.883
LOC105934647	rbx1	ENSFHEP00000001063	ENSFHEP00000033508	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Ring-box 1, E3 ubiquitin protein ligase.	0.419
LOC105939250	cop1	ENSFHEP00000022586	ENSFHEP00000031346	Tribbles pseudokinase 3.	COP1 E3 ubiquitin ligase.	0.860
LOC105939250	det1	ENSFHEP00000022586	ENSFHEP00000023566	Tribbles pseudokinase 3.	DET1 partner of COP1 E3 ubiquitin ligase.	0.449
LOC105939250	stk40	ENSFHEP00000022586	ENSFHEP00000000277	Tribbles pseudokinase 3.	Serine/threonine-protein kinase 40.	0.803
cop1	LOC105921876	ENSFHEP00000031346	ENSFHEP00000000974	COP1 E3 ubiquitin ligase.	Ets variant 5a.	0.853
cop1	LOC105933792	ENSFHEP00000031346	ENSFHEP00000008575	COP1 E3 ubiquitin ligase.	Cullin 4A; Belongs to the cullin family.	0.834
cop1	LOC105934647	ENSFHEP00000031346	ENSFHEP00000001063	COP1 E3 ubiquitin ligase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.932