STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
srd5a13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (265 aa)    
Predicted Functional Partners:
hsd17b3
Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.960
LOC105919965
Cytochrome P450, family 17, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family.
     
 0.958
LOC105933849
Aldo_ket_red domain-containing protein.
   
 
 0.956
AKR1D1
Aldo-keto reductase family 1 member D1.
   
 
 0.956
LOC105917304
Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family.
     
 0.955
CYP19A1
Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.
     
 0.955
LOC105916600
Cytochrome P450, family 19, subfamily A, polypeptide 1a; Belongs to the cytochrome P450 family.
     
 0.955
srd5a3
Steroid 5 alpha-reductase 3.
     
0.954
hsd17b8
Hydroxysteroid (17-beta) dehydrogenase 8; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
     
 0.953
LOC105938357
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family.
     
 0.952
Your Current Organism:
Fundulus heteroclitus
NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.