STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VAV1Vav guanine nucleotide exchange factor 1. (811 aa)    
Predicted Functional Partners:
grb2
Growth factor receptor-bound protein 2b.
    
0.839
ENSPREP00000004672
SH2 domain-containing protein.
   
 0.667
syk
Tyrosine-protein kinase.
   
 0.660
LOC103468233
Tyrosine-protein kinase.
   
 0.660
grap2
GRB2 related adaptor protein 2a.
    
0.657
CDC42
Cell division cycle 42.
   
 0.635
LOC103465423
Cell division cycle 42.
   
 0.635
LOC103477907
Cbl proto-oncogene C, E3 ubiquitin protein ligase.
    
 0.608
LOC103476312
Uncharacterized protein.
    
 0.608
cbl
Cbl proto-oncogene, E3 ubiquitin protein ligase.
    
 0.608
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.