Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
KPNA2Importin subunit alpha; Belongs to the importin alpha family. (525 aa)    
Predicted Functional Partners:
kpnb1
Karyopherin (importin) beta 1.
   
 0.931
ccnb1
Cyclin B1; Belongs to the cyclin family.
   
 0.821
nup50
Nucleoporin 50.
   
 
 0.814
NCBP1
Nuclear cap binding protein subunit 1.
   
 
 0.797
nup153
Nucleoporin 153.
   
 
 0.793
cdc20
Cell division cycle 20 homolog.
   
 
 0.778
cse1l
CSE1 chromosome segregation 1-like (yeast).
   
 
 0.761
ncbp2
Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...]
   
 
 0.761
LOC103474790
Cyclin N-terminal domain containing 2; Belongs to the cyclin family.
   
 0.752
dlgap5
Discs, large (Drosophila) homolog-associated protein 5.
   
  
 0.734
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.