Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
tmem186Transmembrane protein 186. (220 aa)    
Predicted Functional Partners:
ecsit
ECSIT signalling integrator.
    
 0.981
ND3
NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
     
 0.974
ndufaf6
NADH:ubiquinone oxidoreductase complex assembly factor 6.
   
 
 0.895
ndufaf1
NADH:ubiquinone oxidoreductase complex assembly factor 1.
   
 
 0.888
timmdc1
Translocase of inner mitochondrial membrane domain containing 1.
     
 0.846
foxred1
FAD-dependent oxidoreductase domain containing 1.
   
 
 0.846
ndufaf7
Protein arginine methyltransferase NDUFAF7; Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
     
 0.798
ndufaf4
NADH:ubiquinone oxidoreductase complex assembly factor 4.
     
 0.796
heatr3
HEAT repeat containing 3.
    
   0.792
dmac2
Si:ch1073-228b5.2.
   
 
 0.765
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
Server load: low (20%) [HD]