STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
smyd2Uncharacterized protein. (499 aa)    
Predicted Functional Partners:
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.999
parp1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
    
 
 0.833
Map3k2
Protein kinase domain-containing protein.
    
 
 0.753
helz
Helicase with zinc finger.
    
 0.751
CAMKMT
Calmodulin-lysine N-methyltransferase.
     
 0.745
setd7
SET domain containing 7, histone lysine methyltransferase.
   
  
 0.719
plod1
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1a.
   
 0.672
plod2
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2.
   
 0.672
setd3
Protein-histidine N-methyltransferase.
   
 
 0.663
LOC103458261
Nuclear receptor binding SET domain protein 2.
   
 
 0.650
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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