LOC103458615 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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textmining

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protein homology

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Score

LOC103458615

NK2 homeobox 2a. (335 aa)

Predicted Functional Partners:

ENSPREP00000003149

0.675

olig2

0.633

neurod1

0.577

Neurog1

0.567

chrd

0.549

ENSPREP00000005434

0.543

prdm8

0.531

LOC103467741

0.529

foxa2

0.523

LOC103476384

0.513

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000003149	LOC103458615	ENSPREP00000003149	ENSPREP00000001270	BHLH domain-containing protein.	NK2 homeobox 2a.	0.675
ENSPREP00000003149	LOC103476384	ENSPREP00000003149	ENSPREP00000025882	BHLH domain-containing protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.581
ENSPREP00000005434	LOC103458615	ENSPREP00000005434	ENSPREP00000001270	BHLH domain-containing protein.	NK2 homeobox 2a.	0.543
LOC103458615	ENSPREP00000003149	ENSPREP00000001270	ENSPREP00000003149	NK2 homeobox 2a.	BHLH domain-containing protein.	0.675
LOC103458615	ENSPREP00000005434	ENSPREP00000001270	ENSPREP00000005434	NK2 homeobox 2a.	BHLH domain-containing protein.	0.543
LOC103458615	LOC103467741	ENSPREP00000001270	ENSPREP00000002810	NK2 homeobox 2a.	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.529
LOC103458615	LOC103476384	ENSPREP00000001270	ENSPREP00000025882	NK2 homeobox 2a.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.513
LOC103458615	Neurog1	ENSPREP00000001270	ENSPREP00000017486	NK2 homeobox 2a.	Neurogenin 1.	0.567
LOC103458615	chrd	ENSPREP00000001270	ENSPREP00000014581	NK2 homeobox 2a.	Chordin; Belongs to the chordin family.	0.549
LOC103458615	foxa2	ENSPREP00000001270	ENSPREP00000001214	NK2 homeobox 2a.	Forkhead box A2.	0.523
LOC103458615	neurod1	ENSPREP00000001270	ENSPREP00000006308	NK2 homeobox 2a.	Neurogenic differentiation factor.	0.577
LOC103458615	olig2	ENSPREP00000001270	ENSPREP00000005341	NK2 homeobox 2a.	Oligodendrocyte lineage transcription factor 2.	0.633
LOC103458615	prdm8	ENSPREP00000001270	ENSPREP00000004464	NK2 homeobox 2a.	PR domain containing 8b.	0.531
LOC103467741	LOC103458615	ENSPREP00000002810	ENSPREP00000001270	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	NK2 homeobox 2a.	0.529
LOC103476384	ENSPREP00000003149	ENSPREP00000025882	ENSPREP00000003149	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	BHLH domain-containing protein.	0.581
LOC103476384	LOC103458615	ENSPREP00000025882	ENSPREP00000001270	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	NK2 homeobox 2a.	0.513
Neurog1	LOC103458615	ENSPREP00000017486	ENSPREP00000001270	Neurogenin 1.	NK2 homeobox 2a.	0.567
chrd	LOC103458615	ENSPREP00000014581	ENSPREP00000001270	Chordin; Belongs to the chordin family.	NK2 homeobox 2a.	0.549
foxa2	LOC103458615	ENSPREP00000001214	ENSPREP00000001270	Forkhead box A2.	NK2 homeobox 2a.	0.523
neurod1	LOC103458615	ENSPREP00000006308	ENSPREP00000001270	Neurogenic differentiation factor.	NK2 homeobox 2a.	0.577

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.841

expected number of edges:

16

PPI enrichment p-value:

3.86e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000160

Phosphorelay signal transduction system

8 of 82

1.26

1.64

5.36e-07

GO:0007165

Signal transduction

9 of 122

1.14

1.4

5.36e-07

GO:0019538

Protein metabolic process

8 of 194

0.88

0.84

5.34e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

7 of 39

1.52

2.26

1.94e-07

GO:0000155

Phosphorelay sensor kinase activity

6 of 35

1.5

2.0

2.21e-06

GO:0140096

Catalytic activity, acting on a protein

9 of 109

1.19

1.54

1.80e-07

GO:0016740

Transferase activity

8 of 304

0.69

0.54

0.0020

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2313

Phosphorelay signal transduction system, and GGDEF domain

6 of 72

1.19

1.17

0.00018

CL:2397

PAC motif, and Putative diguanylate phosphodiesterase

3 of 12

1.67

1.17

0.0034

CL:2309

Signal transduction, and Flagellar assembly

8 of 171

0.94

0.87

0.00018

CL:2400

Mixed, incl. PAS domain, and SsuA/THI5-like

2 of 6

1.79

0.78

0.0310

CL:2317

Phosphorelay signal transduction system

3 of 29

1.28

0.7

0.0250

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

5 of 58

1.2

0.98

0.0019

KW-0597

Phosphoprotein

5 of 63

1.17

0.95

0.0019

KW-0175

Coiled coil

7 of 254

0.71

0.51

0.0070

KW-0808

Transferase

6 of 237

0.67

0.4

0.0359

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

7 of 29

1.65

2.73

2.51e-08

IPR003594

Histidine kinase/HSP90-like ATPase

8 of 40

1.57

2.65

6.63e-09

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

8 of 41

1.56

2.62

6.63e-09

IPR005467

Histidine kinase domain

7 of 37

1.55

2.38

8.52e-08

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

6 of 35

1.5

1.96

3.24e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00387

Histidine kinase-like ATPases

8 of 39

1.58

2.89

4.69e-10

SM00388

His Kinase A (phosphoacceptor) domain

5 of 35

1.42

1.61

3.40e-05

SM00448

cheY-homologous receiver domain

5 of 55

1.23

1.21

0.00018

SM00091

PAS domain

3 of 21

1.42

1.03

0.0040

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

3 of 21

1.42

1.03

0.0040

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