STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC103468622Immediate early response 2a. (176 aa)    
Predicted Functional Partners:
ppp2r1b
Protein phosphatase 2, regulatory subunit A, beta b.
    
   0.780
LOC103464508
JunB proto-oncogene, AP-1 transcription factor subunit a.
   
  
 0.767
LOC103468371
JunB proto-oncogene, AP-1 transcription factor subunit b.
   
  
 0.767
c-fos
V-fos FBJ murine osteosarcoma viral oncogene homolog Ab.
   
  
 0.749
fosb
FBJ murine osteosarcoma viral oncogene homolog B.
   
  
 0.686
ENSPREP00000027385
Uncharacterized protein.
    
   0.660
PPP2R2C
Protein phosphatase 2 regulatory subunit Bgamma.
    
   0.660
ppp2r2d
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.
    
   0.652
btg1
B-cell translocation gene 1, anti-proliferative.
   
  
 0.600
egr1
Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.
   
 
 0.591
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.