musk protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

musk

Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (623 aa)

Predicted Functional Partners:

DOK7

0.955

wnt11

0.722

lrp4

0.714

agrn

0.711

rapsn

0.657

bdnf

0.614

fgb

0.579

pcbd1

0.576

tgfb2

0.566

ENSPREP00000000894

0.550

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DOK7	agrn	ENSPREP00000020796	ENSPREP00000016797	Docking protein 7.	Agrin.	0.647
DOK7	lrp4	ENSPREP00000020796	ENSPREP00000029758	Docking protein 7.	Low density lipoprotein receptor-related protein 4.	0.474
DOK7	musk	ENSPREP00000020796	ENSPREP00000001424	Docking protein 7.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.955
DOK7	rapsn	ENSPREP00000020796	ENSPREP00000016531	Docking protein 7.	Receptor-associated protein of the synapse, 43kD.	0.644
ENSPREP00000000894	musk	ENSPREP00000000894	ENSPREP00000001424	Matrix metallopeptidase 17b.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.550
agrn	DOK7	ENSPREP00000016797	ENSPREP00000020796	Agrin.	Docking protein 7.	0.647
agrn	lrp4	ENSPREP00000016797	ENSPREP00000029758	Agrin.	Low density lipoprotein receptor-related protein 4.	0.855
agrn	musk	ENSPREP00000016797	ENSPREP00000001424	Agrin.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.711
agrn	rapsn	ENSPREP00000016797	ENSPREP00000016531	Agrin.	Receptor-associated protein of the synapse, 43kD.	0.645
bdnf	musk	ENSPREP00000033461	ENSPREP00000001424	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.614
fgb	musk	ENSPREP00000011828	ENSPREP00000001424	Fibrinogen beta chain.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.579
fgb	pcbd1	ENSPREP00000011828	ENSPREP00000003246	Fibrinogen beta chain.	Pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha.	0.571
lrp4	DOK7	ENSPREP00000029758	ENSPREP00000020796	Low density lipoprotein receptor-related protein 4.	Docking protein 7.	0.474
lrp4	agrn	ENSPREP00000029758	ENSPREP00000016797	Low density lipoprotein receptor-related protein 4.	Agrin.	0.855
lrp4	musk	ENSPREP00000029758	ENSPREP00000001424	Low density lipoprotein receptor-related protein 4.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.714
lrp4	rapsn	ENSPREP00000029758	ENSPREP00000016531	Low density lipoprotein receptor-related protein 4.	Receptor-associated protein of the synapse, 43kD.	0.476
lrp4	wnt11	ENSPREP00000029758	ENSPREP00000014718	Low density lipoprotein receptor-related protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.446
musk	DOK7	ENSPREP00000001424	ENSPREP00000020796	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Docking protein 7.	0.955
musk	ENSPREP00000000894	ENSPREP00000001424	ENSPREP00000000894	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Matrix metallopeptidase 17b.	0.550
musk	agrn	ENSPREP00000001424	ENSPREP00000016797	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Agrin.	0.711

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.842

expected number of edges:

11

PPI enrichment p-value:

0.0142

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001503

Ossification

7 of 108

2.13

4.4

1.78e-10

GO:0045597

Positive regulation of cell differentiation

7 of 478

1.48

2.07

6.58e-07

GO:2000026

Regulation of multicellular organismal development

9 of 838

1.35

2.0

2.63e-08

GO:0051094

Positive regulation of developmental process

8 of 738

1.35

1.87

3.04e-07

GO:0002062

Chondrocyte differentiation

3 of 45

2.14

1.8

0.00032

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005667

Transcription regulator complex

4 of 371

1.35

0.71

0.0270

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31879

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and Runt domain

5 of 30

2.54

4.08

1.43e-08

CL:31881

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and FOG family

3 of 21

2.47

2.18

8.33e-05

CL:31886

Mixed, incl. RUNX3 regulates p14-ARF, and LIM interaction domain

2 of 6

2.84

1.42

0.0027

CL:31925

Mixed, incl. Runt domain, and Paired-box protein 2 C-terminal

2 of 7

2.77

1.38

0.0031

CL:41371

Mixed, incl. Ubiquinone and other terpenoid-quinone biosynthesis, and Osteocalcin/matrix Gla protein

2 of 15

2.44

1.09

0.0102

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8951936

RUNX3 regulates p14-ARF

2 of 6

2.84

1.36

0.0035

MAP-8939246

RUNX1 regulates transcription of genes involved in differentiation of myeloid cells

2 of 4

3.02

1.36

0.0035

MAP-8931987

RUNX1 regulates estrogen receptor mediated transcription

2 of 3

3.14

1.36

0.0035

MAP-8877330

RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

2 of 4

3.02

1.36

0.0035

MAP-8934593

Regulation of RUNX1 Expression and Activity

2 of 8

2.72

1.35

0.0035

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00853

Runt domain

4 of 4

3.32

4.59

4.60e-09

PF08504

Runx inhibition domain

3 of 3

3.32

3.17

1.88e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013524

Runt domain

4 of 4

3.32

4.32

1.44e-08

IPR000040

Acute myeloid leukemia 1 protein (AML1)/Runt

4 of 4

3.32

4.32

1.44e-08

IPR012346

p53/RUNT-type transcription factor, DNA-binding domain superfamily

4 of 7

3.07

4.18

2.26e-08

IPR027384

Runx, central domain superfamily

3 of 3

3.32

3.06

2.94e-06

IPR016554

Runt-related transcription factor RUNX

3 of 3

3.32

3.06

2.94e-06

(more ...)

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