mstn protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

mstn

Myostatin b. (376 aa)

Predicted Functional Partners:

acvr2b

0.970

ACVR1B

0.956

LOC103482409

0.949

LOC103457777

0.901

fst

0.764

fstl3

0.763

myog

0.655

LOC103460036

0.647

acvr2a

0.647

surf1

0.607

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR1B	LOC103457777	ENSPREP00000031367	ENSPREP00000033187	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Myostatin a.	0.943
ACVR1B	LOC103460036	ENSPREP00000031367	ENSPREP00000025642	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.936
ACVR1B	acvr2a	ENSPREP00000031367	ENSPREP00000032549	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.698
ACVR1B	acvr2b	ENSPREP00000031367	ENSPREP00000016094	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.946
ACVR1B	mstn	ENSPREP00000031367	ENSPREP00000001448	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Myostatin b.	0.956
LOC103457777	ACVR1B	ENSPREP00000033187	ENSPREP00000031367	Myostatin a.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.943
LOC103457777	LOC103460036	ENSPREP00000033187	ENSPREP00000025642	Myostatin a.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.588
LOC103457777	LOC103482409	ENSPREP00000033187	ENSPREP00000019609	Myostatin a.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.943
LOC103457777	acvr2a	ENSPREP00000033187	ENSPREP00000032549	Myostatin a.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.588
LOC103457777	acvr2b	ENSPREP00000033187	ENSPREP00000016094	Myostatin a.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.957
LOC103457777	fst	ENSPREP00000033187	ENSPREP00000014118	Myostatin a.	Follistatin a.	0.711
LOC103457777	fstl3	ENSPREP00000033187	ENSPREP00000010992	Myostatin a.	Follistatin-like 3 (secreted glycoprotein).	0.724
LOC103457777	mstn	ENSPREP00000033187	ENSPREP00000001448	Myostatin a.	Myostatin b.	0.901
LOC103460036	ACVR1B	ENSPREP00000025642	ENSPREP00000031367	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.936
LOC103460036	LOC103457777	ENSPREP00000025642	ENSPREP00000033187	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Myostatin a.	0.588
LOC103460036	LOC103482409	ENSPREP00000025642	ENSPREP00000019609	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.936
LOC103460036	acvr2b	ENSPREP00000025642	ENSPREP00000016094	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.910
LOC103460036	mstn	ENSPREP00000025642	ENSPREP00000001448	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Myostatin b.	0.647
LOC103482409	LOC103457777	ENSPREP00000019609	ENSPREP00000033187	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Myostatin a.	0.943
LOC103482409	LOC103460036	ENSPREP00000019609	ENSPREP00000025642	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.936

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.828

expected number of edges:

12

PPI enrichment p-value:

0.00232

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032088

Negative regulation of NF-kappaB transcription factor activity

3 of 47

2.12

1.01

0.0130

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8873

COMM domain, and The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.

10 of 19

3.04

12.98

1.02e-25

CL:8878

COMM domain

8 of 10

3.22

10.99

3.24e-21

CL:8685

Neddylation, and Ankyrin repeat domain-containing protein AN34A/B/C

11 of 146

2.19

8.13

1.12e-21

CL:8882

COMM domain

3 of 5

3.1

3.05

2.89e-06

CL:8901

Mixed, incl. BRCA1-BARD1 complex, and Dendritic cell migration

2 of 5

2.92

1.45

0.0024

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8951664

Neddylation

11 of 406

1.75

4.62

1.08e-16

MAP-597592

Post-translational protein modification

11 of 2250

1.01

1.25

7.18e-09

MAP-392499

Metabolism of proteins

11 of 2844

0.91

1.02

6.26e-08

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07258

COMM domain

8 of 10

3.22

10.77

8.85e-21

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017920

COMM domain

8 of 10

3.22

10.51

2.76e-20

IPR047155

COMM domain-containing protein 4/6/7/8

4 of 4

3.32

4.49

7.19e-09

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