apaf1 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

apaf1

Apoptotic peptidase activating factor 1. (1321 aa)

Predicted Functional Partners:

casp9

0.999

LOC103472206

0.997

LOC103476587

0.997

LOC103458169

0.997

xiap

0.963

leo1

0.947

LOC103466909

0.905

BCL2L1

0.905

aven

0.892

CASP3

0.888

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2L1	CASP3	ENSPREP00000032815	ENSPREP00000001533	BCL2 like 1.	Caspase 3; Belongs to the peptidase C14A family.	0.611
BCL2L1	LOC103458169	ENSPREP00000032815	ENSPREP00000008219	BCL2 like 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.857
BCL2L1	LOC103466909	ENSPREP00000032815	ENSPREP00000006369	BCL2 like 1.	BH4_2 domain-containing protein.	0.903
BCL2L1	LOC103472206	ENSPREP00000032815	ENSPREP00000001314	BCL2 like 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.857
BCL2L1	LOC103476587	ENSPREP00000032815	ENSPREP00000006591	BCL2 like 1.	Cytochrome c, somatic b; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.857
BCL2L1	apaf1	ENSPREP00000032815	ENSPREP00000001466	BCL2 like 1.	Apoptotic peptidase activating factor 1.	0.905
BCL2L1	casp9	ENSPREP00000032815	ENSPREP00000019950	BCL2 like 1.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.917
BCL2L1	xiap	ENSPREP00000032815	ENSPREP00000031057	BCL2 like 1.	X-linked inhibitor of apoptosis.	0.600
CASP3	BCL2L1	ENSPREP00000001533	ENSPREP00000032815	Caspase 3; Belongs to the peptidase C14A family.	BCL2 like 1.	0.611
CASP3	LOC103458169	ENSPREP00000001533	ENSPREP00000008219	Caspase 3; Belongs to the peptidase C14A family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.831
CASP3	LOC103466909	ENSPREP00000001533	ENSPREP00000006369	Caspase 3; Belongs to the peptidase C14A family.	BH4_2 domain-containing protein.	0.611
CASP3	LOC103472206	ENSPREP00000001533	ENSPREP00000001314	Caspase 3; Belongs to the peptidase C14A family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.831
CASP3	LOC103476587	ENSPREP00000001533	ENSPREP00000006591	Caspase 3; Belongs to the peptidase C14A family.	Cytochrome c, somatic b; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.831
CASP3	apaf1	ENSPREP00000001533	ENSPREP00000001466	Caspase 3; Belongs to the peptidase C14A family.	Apoptotic peptidase activating factor 1.	0.888
CASP3	casp9	ENSPREP00000001533	ENSPREP00000019950	Caspase 3; Belongs to the peptidase C14A family.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.986
CASP3	xiap	ENSPREP00000001533	ENSPREP00000031057	Caspase 3; Belongs to the peptidase C14A family.	X-linked inhibitor of apoptosis.	0.989
LOC103458169	BCL2L1	ENSPREP00000008219	ENSPREP00000032815	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	BCL2 like 1.	0.857
LOC103458169	CASP3	ENSPREP00000008219	ENSPREP00000001533	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Caspase 3; Belongs to the peptidase C14A family.	0.831
LOC103458169	LOC103466909	ENSPREP00000008219	ENSPREP00000006369	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	BH4_2 domain-containing protein.	0.857
LOC103458169	LOC103472206	ENSPREP00000008219	ENSPREP00000001314	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.901