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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
e2f1E2F transcription factor 1. (477 aa)    
Predicted Functional Partners:
ENSPREP00000032744
Retinoblastoma 1.
   
 0.999
tfdp1
Transcription factor.
   
 0.993
ccna2
Cyclin A2; Belongs to the cyclin family.
   
 0.983
ccna1
Cyclin A1; Belongs to the cyclin family.
   
 0.983
cdk2
Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.968
e2f2
Si:ch211-160f23.5.
  
 
0.963
skp2
F-box domain-containing protein.
    
 0.874
topbp1
DNA topoisomerase II binding protein 1.
    
 
 0.870
sp1
Sp1 transcription factor.
    
 0.814
ENSPREP00000023356
Retinoblastoma-like 1 (p107).
   
 0.750
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.