ENSPREP00000001888 protein (Poecilia reticulata)

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second shell of interactors

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Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

ENSPREP00000001888

Complement component 7b. (572 aa)

Predicted Functional Partners:

c6

0.570

c7

0.570

VDAC2

0.540

vdac1

0.540

C8A

0.540

c8b

0.540

vdac3

0.540

LOC103476817

0.540

LOC103473231

0.540

c9

0.540

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C8A	ENSPREP00000001888	ENSPREP00000005260	ENSPREP00000001888	Complement C8 alpha chain.	Complement component 7b.	0.540
C8A	LOC103473231	ENSPREP00000005260	ENSPREP00000024198	Complement C8 alpha chain.	Zgc:56235.	0.540
C8A	LOC103476817	ENSPREP00000005260	ENSPREP00000022699	Complement C8 alpha chain.	Voltage-dependent anion channel 2.	0.540
C8A	VDAC2	ENSPREP00000005260	ENSPREP00000004025	Complement C8 alpha chain.	Voltage dependent anion channel 2.	0.540
C8A	c6	ENSPREP00000005260	ENSPREP00000001757	Complement C8 alpha chain.	Complement component 6.	0.872
C8A	c7	ENSPREP00000005260	ENSPREP00000024334	Complement C8 alpha chain.	Complement component 7a.	0.868
C8A	c8b	ENSPREP00000005260	ENSPREP00000005284	Complement C8 alpha chain.	Complement component 8, beta polypeptide.	0.739
C8A	c9	ENSPREP00000005260	ENSPREP00000030247	Complement C8 alpha chain.	Complement component 9.	0.978
C8A	vdac1	ENSPREP00000005260	ENSPREP00000004744	Complement C8 alpha chain.	Voltage-dependent anion channel 1.	0.540
C8A	vdac3	ENSPREP00000005260	ENSPREP00000016725	Complement C8 alpha chain.	Voltage-dependent anion channel 3.	0.540
ENSPREP00000001888	C8A	ENSPREP00000001888	ENSPREP00000005260	Complement component 7b.	Complement C8 alpha chain.	0.540
ENSPREP00000001888	LOC103473231	ENSPREP00000001888	ENSPREP00000024198	Complement component 7b.	Zgc:56235.	0.540
ENSPREP00000001888	LOC103476817	ENSPREP00000001888	ENSPREP00000022699	Complement component 7b.	Voltage-dependent anion channel 2.	0.540
ENSPREP00000001888	VDAC2	ENSPREP00000001888	ENSPREP00000004025	Complement component 7b.	Voltage dependent anion channel 2.	0.540
ENSPREP00000001888	c6	ENSPREP00000001888	ENSPREP00000001757	Complement component 7b.	Complement component 6.	0.570
ENSPREP00000001888	c7	ENSPREP00000001888	ENSPREP00000024334	Complement component 7b.	Complement component 7a.	0.570
ENSPREP00000001888	c8b	ENSPREP00000001888	ENSPREP00000005284	Complement component 7b.	Complement component 8, beta polypeptide.	0.540
ENSPREP00000001888	c9	ENSPREP00000001888	ENSPREP00000030247	Complement component 7b.	Complement component 9.	0.540
ENSPREP00000001888	vdac1	ENSPREP00000001888	ENSPREP00000004744	Complement component 7b.	Voltage-dependent anion channel 1.	0.540
ENSPREP00000001888	vdac3	ENSPREP00000001888	ENSPREP00000016725	Complement component 7b.	Voltage-dependent anion channel 3.	0.540

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.894

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007062

Sister chromatid cohesion

9 of 40

2.67

9.23

1.94e-19

GO:0007064

Mitotic sister chromatid cohesion

8 of 24

2.84

8.98

3.79e-18

GO:0071168

Protein localization to chromatin

6 of 11

3.05

7.22

3.71e-14

GO:0071921

Cohesin loading

4 of 4

3.32

4.95

1.03e-09

GO:0000278

Mitotic cell cycle

10 of 481

1.64

3.61

2.08e-13

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061775

Cohesin loading activity

2 of 2

3.32

1.37

0.0034

GO:0003682

Chromatin binding

4 of 420

1.3

0.61

0.0465

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090694

Scc2-Scc4 cohesin loading complex

4 of 4

3.32

4.73

2.55e-09

GO:0000794

Condensed nuclear chromosome

5 of 49

2.33

3.95

1.16e-08

GO:0000798

Nuclear cohesin complex

3 of 5

3.1

3.26

1.17e-06

GO:0000795

Synaptonemal complex

3 of 22

2.45

2.38e-05

GO:0034990

Nuclear mitotic cohesin complex

2 of 2

3.32

2.17

0.00012

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7532

Cohesin Loading onto Chromatin

11 of 20

3.06

14.81

1.89e-29

CL:7535

Cohesin Loading onto Chromatin

8 of 15

3.04

10.11

7.26e-20

CL:7537

Establishment of Sister Chromatid Cohesion

4 of 6

3.14

4.45

7.59e-09

CL:7552

Cohesin complex

2 of 5

2.92

1.3

0.0044

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2470946

Cohesin Loading onto Chromatin

11 of 20

3.06

15.04

6.30e-30

MAP-68884

Mitotic Telophase/Cytokinesis

11 of 23

3.0

14.76

1.06e-29

MAP-2468052

Establishment of Sister Chromatid Cohesion

7 of 19

2.88

8.23

1.85e-16

MAP-2500257

Resolution of Sister Chromatid Cohesion

7 of 165

1.95

4.08

9.21e-11

MAP-68886

M Phase

11 of 529

1.64

3.95

4.79e-16

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032116

SMC loading complex

4 of 4

3.32

4.69

3.10e-09

GOCC:0090694

Scc2-Scc4 cohesin loading complex

3 of 3

3.32

3.31

1.02e-06

GOCC:0000793

Condensed chromosome

5 of 110

1.98

2.77

1.02e-06

GOCC:0008278

Cohesin complex

3 of 14

2.65

2.57

1.72e-05

GOCC:0034990

Nuclear mitotic cohesin complex

2 of 2

3.32

1.94

0.00032

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0131

Cell cycle

2 of 31

2.13

0.77

0.0368

KW-0539

Nucleus

5 of 1189

0.94

0.52

0.0368

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12830

Sister chromatid cohesion C-terminus

2 of 2

3.32

1.41

0.0029

PF12765

HEAT repeat associated with sister chromatid cohesion

2 of 4

3.02

1.41

0.0029

PF07814

Wings apart-like protein regulation of heterochromatin

2 of 2

3.32

1.41

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033031

Scc2/Nipped-B family

3 of 3

3.32

2.9

5.87e-06

IPR011989

Armadillo-like helical

6 of 228

1.74

2.3

3.38e-06

IPR039874

Wings apart-like protein

2 of 2

3.32

1.48

0.0022

IPR039776

Sister chromatid cohesion protein Pds5

2 of 2

3.32

1.48

0.0022

IPR024986

Sister chromatid cohesion C-terminal domain

2 of 2

3.32

1.48

0.0022

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00968

SMC proteins Flexible Hinge Domain

2 of 7

2.77

1.23

0.0059

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