STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC103466240Protein kinase domain-containing protein. (1352 aa)    
Predicted Functional Partners:
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.978
DCAF7
DDB1 and CUL4 associated factor 7.
   
 
 0.651
sumo1
Small ubiquitin like modifier 1.
    
 0.618
pin1
Peptidyl-prolyl cis-trans isomerase.
    
  0.578
mecp2
Methyl CpG binding protein 2.
    
 0.567
ube2i
Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.538
LOC103468487
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.538
mdm2
MDM2 proto-oncogene.
    
 0.532
LOC103468460
E1A binding protein p300 b.
   
 0.531
LOC103482005
E1A binding protein p300 a.
   
 0.531
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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