hmgcl protein (Poecilia reticulata) - STRING interaction network

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Score

hmgcl

3-hydroxy-3-methylglutaryl-CoA lyase. (298 aa)

Predicted Functional Partners:

LOC103473119

0.991

auh

0.978

oxct1

0.963

aacs

0.959

acaa1

0.951

acat2

0.943

acat1

0.943

acaa2

0.939

bdh1

0.938

bdh2

0.930

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103473119	aacs	ENSPREP00000017837	ENSPREP00000012586	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Acetoacetyl-CoA synthetase.	0.950
LOC103473119	acaa1	ENSPREP00000017837	ENSPREP00000006361	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.991
LOC103473119	acaa2	ENSPREP00000017837	ENSPREP00000016912	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.992
LOC103473119	acat1	ENSPREP00000017837	ENSPREP00000015486	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.993
LOC103473119	acat2	ENSPREP00000017837	ENSPREP00000008323	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.996
LOC103473119	auh	ENSPREP00000017837	ENSPREP00000006396	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	AU RNA binding protein/enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.955
LOC103473119	hmgcl	ENSPREP00000017837	ENSPREP00000001998	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl-CoA lyase.	0.991
LOC103473119	oxct1	ENSPREP00000017837	ENSPREP00000024269	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.956
aacs	LOC103473119	ENSPREP00000012586	ENSPREP00000017837	Acetoacetyl-CoA synthetase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.950
aacs	acaa1	ENSPREP00000012586	ENSPREP00000006361	Acetoacetyl-CoA synthetase.	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.570
aacs	acaa2	ENSPREP00000012586	ENSPREP00000016912	Acetoacetyl-CoA synthetase.	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.568
aacs	acat1	ENSPREP00000012586	ENSPREP00000015486	Acetoacetyl-CoA synthetase.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.953
aacs	acat2	ENSPREP00000012586	ENSPREP00000008323	Acetoacetyl-CoA synthetase.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.953
aacs	auh	ENSPREP00000012586	ENSPREP00000006396	Acetoacetyl-CoA synthetase.	AU RNA binding protein/enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.488
aacs	bdh1	ENSPREP00000012586	ENSPREP00000031863	Acetoacetyl-CoA synthetase.	3-hydroxybutyrate dehydrogenase, type 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.920
aacs	bdh2	ENSPREP00000012586	ENSPREP00000013799	Acetoacetyl-CoA synthetase.	3-hydroxybutyrate dehydrogenase, type 2.	0.930
aacs	hmgcl	ENSPREP00000012586	ENSPREP00000001998	Acetoacetyl-CoA synthetase.	3-hydroxy-3-methylglutaryl-CoA lyase.	0.959
aacs	oxct1	ENSPREP00000012586	ENSPREP00000024269	Acetoacetyl-CoA synthetase.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.932
acaa1	LOC103473119	ENSPREP00000006361	ENSPREP00000017837	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.991
acaa1	aacs	ENSPREP00000006361	ENSPREP00000012586	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acetoacetyl-CoA synthetase.	0.570