FUT4 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

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Score

FUT4

Fucosyltransferase 4. (380 aa)

Predicted Functional Partners:

LOC103463431

0.908

B3GNT3

0.908

LOC103475708

0.908

LOC103471046

0.907

LOC103473546

0.907

LOC103457016

0.907

LOC103457015

0.907

b4galt1

0.907

ENSPREP00000019421

0.907

LOC103456521

0.907

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B3GNT3	FUT4	ENSPREP00000012414	ENSPREP00000002014	Hexosyltransferase.	Fucosyltransferase 4.	0.908
B3GNT3	LOC103456521	ENSPREP00000012414	ENSPREP00000024228	Hexosyltransferase.	Uncharacterized protein.	0.682
B3GNT3	LOC103457015	ENSPREP00000012414	ENSPREP00000015806	Hexosyltransferase.	Uncharacterized protein.	0.682
B3GNT3	LOC103457016	ENSPREP00000012414	ENSPREP00000015797	Hexosyltransferase.	Uncharacterized protein.	0.682
B3GNT3	b4galt1	ENSPREP00000012414	ENSPREP00000016951	Hexosyltransferase.	DP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1, like.	0.690
ENSPREP00000019421	FUT4	ENSPREP00000019421	ENSPREP00000002014	Hexosyltransferase.	Fucosyltransferase 4.	0.907
ENSPREP00000019421	LOC103456521	ENSPREP00000019421	ENSPREP00000024228	Hexosyltransferase.	Uncharacterized protein.	0.669
ENSPREP00000019421	LOC103457015	ENSPREP00000019421	ENSPREP00000015806	Hexosyltransferase.	Uncharacterized protein.	0.669
ENSPREP00000019421	LOC103457016	ENSPREP00000019421	ENSPREP00000015797	Hexosyltransferase.	Uncharacterized protein.	0.669
ENSPREP00000019421	b4galt1	ENSPREP00000019421	ENSPREP00000016951	Hexosyltransferase.	DP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1, like.	0.669
FUT4	B3GNT3	ENSPREP00000002014	ENSPREP00000012414	Fucosyltransferase 4.	Hexosyltransferase.	0.908
FUT4	ENSPREP00000019421	ENSPREP00000002014	ENSPREP00000019421	Fucosyltransferase 4.	Hexosyltransferase.	0.907
FUT4	LOC103456521	ENSPREP00000002014	ENSPREP00000024228	Fucosyltransferase 4.	Uncharacterized protein.	0.907
FUT4	LOC103457015	ENSPREP00000002014	ENSPREP00000015806	Fucosyltransferase 4.	Uncharacterized protein.	0.907
FUT4	LOC103457016	ENSPREP00000002014	ENSPREP00000015797	Fucosyltransferase 4.	Uncharacterized protein.	0.907
FUT4	LOC103463431	ENSPREP00000002014	ENSPREP00000012409	Fucosyltransferase 4.	Hexosyltransferase.	0.908
FUT4	LOC103471046	ENSPREP00000002014	ENSPREP00000005946	Fucosyltransferase 4.	Hexosyltransferase.	0.907
FUT4	LOC103473546	ENSPREP00000002014	ENSPREP00000007567	Fucosyltransferase 4.	Hexosyltransferase.	0.907
FUT4	LOC103475708	ENSPREP00000002014	ENSPREP00000030761	Fucosyltransferase 4.	Hexosyltransferase.	0.908
FUT4	b4galt1	ENSPREP00000002014	ENSPREP00000016951	Fucosyltransferase 4.	DP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1, like.	0.907

page 1 of 4

Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009252

Peptidoglycan biosynthetic process

8 of 34

2.03

4.81

2.24e-12

GO:0008360

Regulation of cell shape

8 of 49

1.88

4.25

3.90e-12

GO:0071555

Cell wall organization

8 of 59

1.79

3.91

8.16e-12

GO:0051301

Cell division

8 of 66

1.75

3.69

1.56e-11

GO:0007049

Cell cycle

7 of 63

1.71

3.15

1.41e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016881

Acid-amino acid ligase activity

5 of 17

2.13

3.14

3.12e-07

GO:0047480

UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity

2 of 2

2.66

1.28

0.0047

GO:0008766

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity

2 of 2

2.66

1.28

0.0047

GO:0043168

Anion binding

7 of 794

0.61

0.36

0.0471

GO:0043167

Ion binding

9 of 1444

0.46

0.29

0.0471

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:25309529

(2014) L,L-diaminopimelate aminotransferase (DapL): a putative target for the development of narrow-spectrum antibacterial compounds.

2 of 4

2.36

1.07

0.0105

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1162

Cell shape

8 of 15

2.39

6.72

4.58e-15

CL:1164

Cell shape

7 of 10

2.51

6.47

7.15e-14

CL:1157

Mixed, incl. Cell shape, and Cell division site

9 of 33

2.1

5.82

4.58e-15

CL:1166

MurE/MurF, N-terminal, and UDP-glycosyltransferase activity

5 of 5

2.66

4.92

3.97e-10

CL:1638

Lysine biosynthesis

2 of 5

2.26

1.13

0.0079

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

dsy00550

Peptidoglycan biosynthesis

8 of 29

2.1

5.5

6.05e-14

dsy00300

Lysine biosynthesis

5 of 22

2.02

3.27

6.80e-08

dsy01502

Vancomycin resistance

4 of 14

2.12

2.92

9.39e-07

dsy00471

D-Glutamine and D-glutamate metabolism

2 of 3

2.49

1.65

0.00089

dsy01100

Metabolic pathways

10 of 692

0.82

0.85

8.17e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0573

Peptidoglycan synthesis

8 of 19

2.29

6.37

6.93e-15

KW-0961

Cell wall biogenesis/degradation

8 of 23

2.2

6.09

9.12e-15

KW-0132

Cell division

7 of 31

2.02

4.53

1.23e-11

KW-0131

Cell cycle

7 of 31

2.02

4.53

1.23e-11

KW-0436

Ligase

5 of 73

1.5

1.84

9.57e-06

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02875

Mur ligase family, glutamate ligase domain

5 of 7

2.52

4.14

9.63e-09

PF08245

Mur ligase middle domain

5 of 9

2.41

4.01

1.21e-08

PF01225

Mur ligase family, catalytic domain

4 of 4

2.66

3.56

2.06e-07

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036615

Mur ligase, C-terminal domain superfamily

5 of 7

2.52

3.95

2.40e-08

IPR004101

Mur ligase, C-terminal

5 of 7

2.52

3.95

2.40e-08

IPR036565

Mur-like, catalytic domain superfamily

5 of 9

2.41

3.87

2.40e-08

IPR013221

Mur ligase, central

5 of 9

2.41

3.87

2.40e-08

IPR000713

Mur ligase, N-terminal catalytic domain

4 of 4

2.66

3.47

3.08e-07

(more ...)

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