Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
tgm2Transglutaminase 2b. (678 aa)    
Predicted Functional Partners:
f2
Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.
    
 0.584
LOC103460587
Uncharacterized protein.
    
 0.524
serpind1
Serpin peptidase inhibitor, clade D (heparin cofactor), member 1; Belongs to the serpin family.
     
 0.521
serpinc1
Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family.
     
 0.506
LOC103474919
Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family.
     
 0.480
ENSPREP00000008452
Uncharacterized protein.
    
 0.476
ENSPREP00000008498
Uncharacterized protein.
    
 0.476
LOC103479045
Uncharacterized protein.
    
 0.476
fga
Fibrinogen alpha chain.
   
 0.459
egf
Epidermal growth factor.
     
 0.440
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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