Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ikzf1IKAROS family zinc finger 1 (Ikaros). (564 aa)    
Predicted Functional Partners:
crbn
Cereblon.
    
 
 0.888
rag1
V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...]
   
 
 0.738
spi1
Spi-1 proto-oncogene b.
   
 0.641
LOC103477443
Runt-related transcription factor.
   
 0.633
myb
V-myb avian myeloblastosis viral oncogene homolog.
   
 0.618
lck
Tyrosine-protein kinase.
   
 0.603
csnk1a1
Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily.
    
 0.573
ENSPREP00000032134
Forkhead box N1.
    
 0.554
rag2
Recombination activating gene 2.
    
 
 0.518
ddb1
Damage-specific DNA binding protein 1.
    
 0.517
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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