hacl1 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

hacl1

2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (568 aa)

Predicted Functional Partners:

ENSPREP00000022666

0.970

LOC103460472

0.960

pex5

0.946

zmynd19

0.906

adhfe1

0.800

cs

0.800

bckdha

0.797

acad11

0.777

LOC103468992

0.749

LOC103459585

0.749

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000022666	acad11	ENSPREP00000022666	ENSPREP00000013666	Peroxisomal biogenesis factor 5-like a.	Acyl-CoA dehydrogenase family, member 11.	0.500
ENSPREP00000022666	hacl1	ENSPREP00000022666	ENSPREP00000002472	Peroxisomal biogenesis factor 5-like a.	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family.	0.970
LOC103459585	LOC103468992	ENSPREP00000019299	ENSPREP00000016908	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.902
LOC103459585	bckdha	ENSPREP00000019299	ENSPREP00000024063	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.988
LOC103459585	hacl1	ENSPREP00000019299	ENSPREP00000002472	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family.	0.749
LOC103460472	acad11	ENSPREP00000001447	ENSPREP00000013666	Peroxisomal biogenesis factor 5-like b.	Acyl-CoA dehydrogenase family, member 11.	0.500
LOC103460472	hacl1	ENSPREP00000001447	ENSPREP00000002472	Peroxisomal biogenesis factor 5-like b.	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family.	0.960
LOC103460472	pex5	ENSPREP00000001447	ENSPREP00000018308	Peroxisomal biogenesis factor 5-like b.	Peroxisomal biogenesis factor 5.	0.906
LOC103468992	LOC103459585	ENSPREP00000016908	ENSPREP00000019299	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.902
LOC103468992	bckdha	ENSPREP00000016908	ENSPREP00000024063	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.988
LOC103468992	hacl1	ENSPREP00000016908	ENSPREP00000002472	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family.	0.749
acad11	ENSPREP00000022666	ENSPREP00000013666	ENSPREP00000022666	Acyl-CoA dehydrogenase family, member 11.	Peroxisomal biogenesis factor 5-like a.	0.500
acad11	LOC103460472	ENSPREP00000013666	ENSPREP00000001447	Acyl-CoA dehydrogenase family, member 11.	Peroxisomal biogenesis factor 5-like b.	0.500
acad11	hacl1	ENSPREP00000013666	ENSPREP00000002472	Acyl-CoA dehydrogenase family, member 11.	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family.	0.777
acad11	pex5	ENSPREP00000013666	ENSPREP00000018308	Acyl-CoA dehydrogenase family, member 11.	Peroxisomal biogenesis factor 5.	0.500
adhfe1	hacl1	ENSPREP00000001695	ENSPREP00000002472	Alcohol dehydrogenase iron containing 1.	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family.	0.800
bckdha	LOC103459585	ENSPREP00000024063	ENSPREP00000019299	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.988
bckdha	LOC103468992	ENSPREP00000024063	ENSPREP00000016908	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.988
bckdha	cs	ENSPREP00000024063	ENSPREP00000033337	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	Citrate synthase; Belongs to the citrate synthase family.	0.848
bckdha	hacl1	ENSPREP00000024063	ENSPREP00000002472	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family.	0.797