ppt2 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

ppt2

Palmitoyl-protein thioesterase 2. (301 aa)

Predicted Functional Partners:

ppt1

0.911

mecr

0.904

LOC103477738

0.902

DDAH1

0.696

skiv2l

0.689

acsl3

0.667

LOC103479395

0.667

LOC103470977

0.667

ACSL1

0.655

LOC103475331

0.655

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACSL1	LOC103470977	ENSPREP00000003059	ENSPREP00000030920	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 4a.	0.765
ACSL1	LOC103475331	ENSPREP00000003059	ENSPREP00000005590	Acyl-CoA synthetase long chain family member 1.	AMP-binding domain-containing protein.	0.607
ACSL1	LOC103477738	ENSPREP00000003059	ENSPREP00000004750	Acyl-CoA synthetase long chain family member 1.	Zgc:66024.	0.655
ACSL1	LOC103479395	ENSPREP00000003059	ENSPREP00000025116	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 3b.	0.763
ACSL1	acsl3	ENSPREP00000003059	ENSPREP00000015628	Acyl-CoA synthetase long chain family member 1.	Uncharacterized protein.	0.763
ACSL1	ppt1	ENSPREP00000003059	ENSPREP00000014938	Acyl-CoA synthetase long chain family member 1.	Palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile).	0.662
ACSL1	ppt2	ENSPREP00000003059	ENSPREP00000002558	Acyl-CoA synthetase long chain family member 1.	Palmitoyl-protein thioesterase 2.	0.655
DDAH1	ppt2	ENSPREP00000031262	ENSPREP00000002558	Dimethylarginine dimethylaminohydrolase 1.	Palmitoyl-protein thioesterase 2.	0.696
DDAH1	skiv2l	ENSPREP00000031262	ENSPREP00000003206	Dimethylarginine dimethylaminohydrolase 1.	SKI2 homolog, superkiller viralicidic activity 2-like.	0.692
LOC103470977	ACSL1	ENSPREP00000030920	ENSPREP00000003059	Acyl-CoA synthetase long chain family member 4a.	Acyl-CoA synthetase long chain family member 1.	0.765
LOC103470977	LOC103475331	ENSPREP00000030920	ENSPREP00000005590	Acyl-CoA synthetase long chain family member 4a.	AMP-binding domain-containing protein.	0.766
LOC103470977	LOC103477738	ENSPREP00000030920	ENSPREP00000004750	Acyl-CoA synthetase long chain family member 4a.	Zgc:66024.	0.667
LOC103470977	LOC103479395	ENSPREP00000030920	ENSPREP00000025116	Acyl-CoA synthetase long chain family member 4a.	Acyl-CoA synthetase long chain family member 3b.	0.609
LOC103470977	acsl3	ENSPREP00000030920	ENSPREP00000015628	Acyl-CoA synthetase long chain family member 4a.	Uncharacterized protein.	0.609
LOC103470977	ppt1	ENSPREP00000030920	ENSPREP00000014938	Acyl-CoA synthetase long chain family member 4a.	Palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile).	0.677
LOC103470977	ppt2	ENSPREP00000030920	ENSPREP00000002558	Acyl-CoA synthetase long chain family member 4a.	Palmitoyl-protein thioesterase 2.	0.667
LOC103475331	ACSL1	ENSPREP00000005590	ENSPREP00000003059	AMP-binding domain-containing protein.	Acyl-CoA synthetase long chain family member 1.	0.607
LOC103475331	LOC103470977	ENSPREP00000005590	ENSPREP00000030920	AMP-binding domain-containing protein.	Acyl-CoA synthetase long chain family member 4a.	0.766
LOC103475331	LOC103477738	ENSPREP00000005590	ENSPREP00000004750	AMP-binding domain-containing protein.	Zgc:66024.	0.655
LOC103475331	LOC103479395	ENSPREP00000005590	ENSPREP00000025116	AMP-binding domain-containing protein.	Acyl-CoA synthetase long chain family member 3b.	0.760

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009107

Lipoate biosynthetic process

4 of 4

2.32

2.47

1.80e-05

GO:0009249

Protein lipoylation

4 of 5

2.22

2.42

1.80e-05

GO:0044272

Sulfur compound biosynthetic process

5 of 32

1.52

1.65

6.40e-05

GO:0032787

Monocarboxylic acid metabolic process

5 of 53

1.3

1.24

0.00032

GO:0019752

Carboxylic acid metabolic process

7 of 177

0.92

0.81

0.00038

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033819

Lipoyl(octanoyl) transferase activity

3 of 3

2.32

1.65

0.00080

GO:0016746

Acyltransferase activity

4 of 47

1.25

0.81

0.0103

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 728

0.46

0.35

0.0078

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:788

Glycine, serine and threonine metabolism, and Lipoic acid metabolism

7 of 16

1.96

3.88

5.79e-10

CL:809

Lipoic acid metabolism, and Lipoyl

5 of 5

2.32

3.72

3.59e-08

CL:723

Ribonucleoside monophosphate metabolic process, and Glycine, serine and threonine metabolism

8 of 51

1.52

2.55

4.37e-09

CL:720

Small molecule metabolic process, and Citrate cycle (TCA cycle)

9 of 186

1.01

1.14

8.71e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00785

Lipoic acid metabolism

4 of 4

2.32

2.92

2.04e-06

map01100

Metabolic pathways

10 of 691

0.48

0.38

0.0026

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

9 of 532

0.55

0.4

0.0067

GOCC:0005622

Intracellular

11 of 902

0.41

0.32

0.0067

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0450

Lipoyl

2 of 2

2.32

1.08

0.0100

KW-0436

Ligase

4 of 47

1.25

0.82

0.0100

KW-0547

Nucleotide-binding

6 of 260

0.69

0.41

0.0328

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03099

Biotin/lipoate A/B protein ligase family

3 of 4

2.2

1.59

0.00095

PF10437

Bacterial lipoate protein ligase C-terminus

2 of 2

2.32

0.91

0.0210

PF00364

Biotin-requiring enzyme

2 of 3

2.15

0.88

0.0233

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004562

Lipoyltransferase/lipoate-protein ligase

3 of 3

2.32

1.52

0.0014

IPR004143

Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain

3 of 4

2.2

1.5

0.0014

IPR022310

NAD/GMP synthase

2 of 2

2.32

0.85

0.0279

IPR019491

Lipoate protein ligase, C-terminal

2 of 2

2.32

0.85

0.0279

IPR003016

2-oxo acid dehydrogenase, lipoyl-binding site

2 of 2

2.32

0.85

0.0279

(more ...)

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