LOC103468869 protein (Poecilia reticulata) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

LOC103468869

Arf-GAP domain-containing protein. (146 aa)

Predicted Functional Partners:

LOC103468867

0.659

LOC103468850

0.641

MYADML2

0.636

myadml2

0.636

mapk8

0.636

lrrc18

0.636

vstm4

0.636

LOC103468852

0.633

pcyt2

0.522

PCYT2

0.522

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103468850	LOC103468852	ENSPREP00000003316	ENSPREP00000003213	Transmembrane channel-like protein.	Notum, palmitoleoyl-protein carboxylesterase a.	0.642
LOC103468850	LOC103468867	ENSPREP00000003316	ENSPREP00000002717	Transmembrane channel-like protein.	Uncharacterized protein.	0.656
LOC103468850	LOC103468869	ENSPREP00000003316	ENSPREP00000002600	Transmembrane channel-like protein.	Arf-GAP domain-containing protein.	0.641
LOC103468850	MYADML2	ENSPREP00000003316	ENSPREP00000000578	Transmembrane channel-like protein.	Myeloid associated differentiation marker like 2.	0.643
LOC103468850	PCYT2	ENSPREP00000003316	ENSPREP00000003081	Transmembrane channel-like protein.	Phosphate cytidylyltransferase 2, ethanolamine.	0.538
LOC103468850	lrrc18	ENSPREP00000003316	ENSPREP00000031760	Transmembrane channel-like protein.	Leucine rich repeat containing 18b.	0.663
LOC103468850	mapk8	ENSPREP00000003316	ENSPREP00000031694	Transmembrane channel-like protein.	Mitogen-activated protein kinase.	0.639
LOC103468850	myadml2	ENSPREP00000003316	ENSPREP00000003169	Transmembrane channel-like protein.	Myeloid-associated differentiation marker-like 2.	0.643
LOC103468850	pcyt2	ENSPREP00000003316	ENSPREP00000000574	Transmembrane channel-like protein.	Phosphate cytidylyltransferase 2, ethanolamine.	0.538
LOC103468850	vstm4	ENSPREP00000003316	ENSPREP00000031777	Transmembrane channel-like protein.	V-set and transmembrane domain containing 4b.	0.633
LOC103468852	LOC103468850	ENSPREP00000003213	ENSPREP00000003316	Notum, palmitoleoyl-protein carboxylesterase a.	Transmembrane channel-like protein.	0.642
LOC103468852	LOC103468867	ENSPREP00000003213	ENSPREP00000002717	Notum, palmitoleoyl-protein carboxylesterase a.	Uncharacterized protein.	0.633
LOC103468852	LOC103468869	ENSPREP00000003213	ENSPREP00000002600	Notum, palmitoleoyl-protein carboxylesterase a.	Arf-GAP domain-containing protein.	0.633
LOC103468852	MYADML2	ENSPREP00000003213	ENSPREP00000000578	Notum, palmitoleoyl-protein carboxylesterase a.	Myeloid associated differentiation marker like 2.	0.643
LOC103468852	PCYT2	ENSPREP00000003213	ENSPREP00000003081	Notum, palmitoleoyl-protein carboxylesterase a.	Phosphate cytidylyltransferase 2, ethanolamine.	0.528
LOC103468852	lrrc18	ENSPREP00000003213	ENSPREP00000031760	Notum, palmitoleoyl-protein carboxylesterase a.	Leucine rich repeat containing 18b.	0.633
LOC103468852	mapk8	ENSPREP00000003213	ENSPREP00000031694	Notum, palmitoleoyl-protein carboxylesterase a.	Mitogen-activated protein kinase.	0.633
LOC103468852	myadml2	ENSPREP00000003213	ENSPREP00000003169	Notum, palmitoleoyl-protein carboxylesterase a.	Myeloid-associated differentiation marker-like 2.	0.643
LOC103468852	pcyt2	ENSPREP00000003213	ENSPREP00000000574	Notum, palmitoleoyl-protein carboxylesterase a.	Phosphate cytidylyltransferase 2, ethanolamine.	0.528
LOC103468852	vstm4	ENSPREP00000003213	ENSPREP00000031777	Notum, palmitoleoyl-protein carboxylesterase a.	V-set and transmembrane domain containing 4b.	0.633

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.842

expected number of edges:

11

PPI enrichment p-value:

0.0142

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001503

Ossification

7 of 108

2.13

4.4

1.78e-10

GO:0045597

Positive regulation of cell differentiation

7 of 478

1.48

2.07

6.58e-07

GO:2000026

Regulation of multicellular organismal development

9 of 838

1.35

2.0

2.63e-08

GO:0051094

Positive regulation of developmental process

8 of 738

1.35

1.87

3.04e-07

GO:0002062

Chondrocyte differentiation

3 of 45

2.14

1.8

0.00032

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005667

Transcription regulator complex

4 of 371

1.35

0.71

0.0270

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31879

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and Runt domain

5 of 30

2.54

4.08

1.43e-08

CL:31881

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and FOG family

3 of 21

2.47

2.18

8.33e-05

CL:31886

Mixed, incl. RUNX3 regulates p14-ARF, and LIM interaction domain

2 of 6

2.84

1.42

0.0027

CL:31925

Mixed, incl. Runt domain, and Paired-box protein 2 C-terminal

2 of 7

2.77

1.38

0.0031

CL:41371

Mixed, incl. Ubiquinone and other terpenoid-quinone biosynthesis, and Osteocalcin/matrix Gla protein

2 of 15

2.44

1.09

0.0102

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8951936

RUNX3 regulates p14-ARF

2 of 6

2.84

1.36

0.0035

MAP-8939246

RUNX1 regulates transcription of genes involved in differentiation of myeloid cells

2 of 4

3.02

1.36

0.0035

MAP-8931987

RUNX1 regulates estrogen receptor mediated transcription

2 of 3

3.14

1.36

0.0035

MAP-8877330

RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

2 of 4

3.02

1.36

0.0035

MAP-8934593

Regulation of RUNX1 Expression and Activity

2 of 8

2.72

1.35

0.0035

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00853

Runt domain

4 of 4

3.32

4.59

4.60e-09

PF08504

Runx inhibition domain

3 of 3

3.32

3.17

1.88e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013524

Runt domain

4 of 4

3.32

4.32

1.44e-08

IPR000040

Acute myeloid leukemia 1 protein (AML1)/Runt

4 of 4

3.32

4.32

1.44e-08

IPR012346

p53/RUNT-type transcription factor, DNA-binding domain superfamily

4 of 7

3.07

4.18

2.26e-08

IPR027384

Runx, central domain superfamily

3 of 3

3.32

3.06

2.94e-06

IPR016554

Runt-related transcription factor RUNX

3 of 3

3.32

3.06

2.94e-06

(more ...)

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