frs3 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

frs3

Fibroblast growth factor receptor substrate 3. (627 aa)

Predicted Functional Partners:

grb2

0.953

ptpn6

0.836

LOC103467098

0.836

ptpn11

0.836

sos1

0.806

sos2

0.806

ret

0.785

LOC103469672

0.730

ENSPREP00000013954

0.713

LOC103477293

0.713

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000013954	LOC103467098	ENSPREP00000013954	ENSPREP00000016883	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.551
ENSPREP00000013954	frs3	ENSPREP00000013954	ENSPREP00000002675	Uncharacterized protein.	Fibroblast growth factor receptor substrate 3.	0.713
ENSPREP00000013954	grb2	ENSPREP00000013954	ENSPREP00000022510	Uncharacterized protein.	Growth factor receptor-bound protein 2b.	0.771
ENSPREP00000013954	ptpn11	ENSPREP00000013954	ENSPREP00000024560	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.551
ENSPREP00000013954	ptpn6	ENSPREP00000013954	ENSPREP00000016776	Uncharacterized protein.	Protein tyrosine phosphatase non-receptor type 6.	0.526
ENSPREP00000013954	sos1	ENSPREP00000013954	ENSPREP00000008888	Uncharacterized protein.	Son of sevenless homolog 1 (Drosophila).	0.557
ENSPREP00000013954	sos2	ENSPREP00000013954	ENSPREP00000026590	Uncharacterized protein.	Son of sevenless homolog 2 (Drosophila).	0.557
LOC103467098	ENSPREP00000013954	ENSPREP00000016883	ENSPREP00000013954	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Uncharacterized protein.	0.551
LOC103467098	LOC103469672	ENSPREP00000016883	ENSPREP00000001007	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Fibroblast growth factor receptor.	0.534
LOC103467098	LOC103477293	ENSPREP00000016883	ENSPREP00000014037	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Fibroblast growth factor receptor.	0.551
LOC103467098	frs3	ENSPREP00000016883	ENSPREP00000002675	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Fibroblast growth factor receptor substrate 3.	0.836
LOC103467098	grb2	ENSPREP00000016883	ENSPREP00000022510	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Growth factor receptor-bound protein 2b.	0.948
LOC103467098	ptpn11	ENSPREP00000016883	ENSPREP00000024560	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.901
LOC103467098	ret	ENSPREP00000016883	ENSPREP00000003385	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	0.660
LOC103467098	sos1	ENSPREP00000016883	ENSPREP00000008888	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Son of sevenless homolog 1 (Drosophila).	0.835
LOC103467098	sos2	ENSPREP00000016883	ENSPREP00000026590	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Son of sevenless homolog 2 (Drosophila).	0.835
LOC103469672	LOC103467098	ENSPREP00000001007	ENSPREP00000016883	Fibroblast growth factor receptor.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.534
LOC103469672	frs3	ENSPREP00000001007	ENSPREP00000002675	Fibroblast growth factor receptor.	Fibroblast growth factor receptor substrate 3.	0.730
LOC103469672	grb2	ENSPREP00000001007	ENSPREP00000022510	Fibroblast growth factor receptor.	Growth factor receptor-bound protein 2b.	0.916
LOC103469672	ptpn11	ENSPREP00000001007	ENSPREP00000024560	Fibroblast growth factor receptor.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.534