STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
otud5OTU deubiquitinase 5a. (551 aa)    
Predicted Functional Partners:
traf3
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.970
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.905
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
    
  0.829
rps27a
Ribosomal protein S27a.
    
 0.824
ubb
Uncharacterized protein.
    
 0.767
LOC103473189
Uncharacterized protein.
    
 0.767
ENSPREP00000009964
Ubiquitin-like domain-containing protein.
    
 0.702
atg3
Autophagy-related protein 3.
   
  
 0.633
SART1
Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP.
   
    0.602
otud7b
OTU deubiquitinase 7B.
    
 
 0.593
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
Server load: low (22%) [HD]