otud5 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

otud5

OTU deubiquitinase 5a. (551 aa)

Predicted Functional Partners:

traf3

0.952

rps27a

0.930

uba52

0.894

ubb

0.798

LOC103473189

0.798

ENSPREP00000009964

0.710

SART1

0.598

atg3

0.580

stambpl1

0.569

ubr5

0.503

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000009964	otud5	ENSPREP00000009964	ENSPREP00000002784	Ubiquitin-like domain-containing protein.	OTU deubiquitinase 5a.	0.710
ENSPREP00000009964	rps27a	ENSPREP00000009964	ENSPREP00000018427	Ubiquitin-like domain-containing protein.	Ribosomal protein S27a.	0.924
ENSPREP00000009964	stambpl1	ENSPREP00000009964	ENSPREP00000002199	Ubiquitin-like domain-containing protein.	STAM binding protein-like 1.	0.779
ENSPREP00000009964	traf3	ENSPREP00000009964	ENSPREP00000006242	Ubiquitin-like domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.567
ENSPREP00000009964	uba52	ENSPREP00000009964	ENSPREP00000016516	Ubiquitin-like domain-containing protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.954
ENSPREP00000009964	ubr5	ENSPREP00000009964	ENSPREP00000024748	Ubiquitin-like domain-containing protein.	Ubiquitin protein ligase E3 component n-recognin 5.	0.562
LOC103473189	otud5	ENSPREP00000021152	ENSPREP00000002784	Uncharacterized protein.	OTU deubiquitinase 5a.	0.798
LOC103473189	rps27a	ENSPREP00000021152	ENSPREP00000018427	Uncharacterized protein.	Ribosomal protein S27a.	0.953
LOC103473189	stambpl1	ENSPREP00000021152	ENSPREP00000002199	Uncharacterized protein.	STAM binding protein-like 1.	0.790
LOC103473189	traf3	ENSPREP00000021152	ENSPREP00000006242	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.651
LOC103473189	uba52	ENSPREP00000021152	ENSPREP00000016516	Uncharacterized protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.972
LOC103473189	ubr5	ENSPREP00000021152	ENSPREP00000024748	Uncharacterized protein.	Ubiquitin protein ligase E3 component n-recognin 5.	0.664
SART1	otud5	ENSPREP00000000100	ENSPREP00000002784	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP.	OTU deubiquitinase 5a.	0.598
atg3	otud5	ENSPREP00000026100	ENSPREP00000002784	Autophagy-related protein 3.	OTU deubiquitinase 5a.	0.580
otud5	ENSPREP00000009964	ENSPREP00000002784	ENSPREP00000009964	OTU deubiquitinase 5a.	Ubiquitin-like domain-containing protein.	0.710
otud5	LOC103473189	ENSPREP00000002784	ENSPREP00000021152	OTU deubiquitinase 5a.	Uncharacterized protein.	0.798
otud5	SART1	ENSPREP00000002784	ENSPREP00000000100	OTU deubiquitinase 5a.	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP.	0.598
otud5	atg3	ENSPREP00000002784	ENSPREP00000026100	OTU deubiquitinase 5a.	Autophagy-related protein 3.	0.580
otud5	rps27a	ENSPREP00000002784	ENSPREP00000018427	OTU deubiquitinase 5a.	Ribosomal protein S27a.	0.930
otud5	stambpl1	ENSPREP00000002784	ENSPREP00000002199	OTU deubiquitinase 5a.	STAM binding protein-like 1.	0.569

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.802

expected number of edges:

11

PPI enrichment p-value:

2.54e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045638

Negative regulation of myeloid cell differentiation

4 of 65

2.05

1.87

0.00019

GO:0045637

Regulation of myeloid cell differentiation

5 of 151

1.78

1.81

0.00012

GO:0045596

Negative regulation of cell differentiation

6 of 451

1.39

0.00019

GO:0007389

Pattern specification process

5 of 328

1.45

1.36

0.00039

GO:0009880

Embryonic pattern specification

3 of 55

2.0

1.34

0.0025

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000978

RNA polymerase II cis-regulatory region sequence-specific DNA binding

9 of 969

1.23

1.66

1.06e-07

GO:0003700

DNA-binding transcription factor activity

10 of 1187

1.19

1.64

1.60e-08

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

5 of 326

1.45

1.52

0.00010

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

9 of 1118

1.17

1.51

1.51e-07

GO:0003677

DNA binding

10 of 2214

0.92

1.0

6.34e-07

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:22829811

(2012) Epigenetic alterations in bladder cancer and their potential clinical implications.

4 of 17

2.64

2.58

1.63e-05

PMID:22495965

(2012) A novel 13 base pair insertion in the sonic hedgehog ZRS limb enhancer (ZRSLMBR1) causes preaxial polydactyly with triphalangeal thumb.

3 of 9

2.79

1.71

0.00076

PMID:26572684

(2015) Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRLMpJ mouse.

3 of 11

2.7

1.68

0.00084

PMID:36418415

(2022) The autism-associated Meis2 gene is necessary for cardiac baroreflex regulation in mice.

3 of 13

2.63

1.64

0.00097

PMID:28874668

(2017) Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation.

3 of 19

2.46

1.45

0.0021

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:26589

Embryonic skeletal system morphogenesis, and N-terminal of Homeobox Meis and PKNOX1

6 of 25

2.64

5.58

1.61e-11

CL:26624

Mixed, incl. Protein of unknown function (DUF3528), and N-terminal of Homeobox Meis and PKNOX1

4 of 5

3.17

4.61

3.85e-09

CL:26433

Homeobox, and Neuron fate commitment

7 of 125

2.01

4.2

1.26e-10

CL:32174

Mixed, incl. Adiponectin binding, and G2 nidogen domain and fibulin

2 of 7

2.72

1.24

0.0055

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa05202

Transcriptional misregulation in cancer

4 of 141

1.72

1.63

0.00027

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005634

Nucleus

9 of 3900

0.63

0.4

0.0259

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0371

Homeobox

7 of 203

1.8

3.38

1.55e-09

KW-0238

DNA-binding

8 of 642

1.36

2.01

3.42e-08

KW-0539

Nucleus

8 of 1146

1.11

1.29

2.14e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16493

N-terminal of Homeobox Meis and PKNOX1

2 of 5

2.87

1.04

0.0130

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00389

Homeodomain

7 of 208

1.79

3.25

3.60e-09

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