Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ENSPREP00000002926TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (196 aa)    
Predicted Functional Partners:
ENSPREP00000020797
TNFR-Cys domain-containing protein.
    
 0.999
ENSPREP00000002275
DED domain-containing protein.
    
 0.997
ENSPREP00000015380
TNFR-Cys domain-containing protein.
    
 0.997
LOC103478931
Uncharacterized protein; Belongs to the peptidase C14A family.
    
 0.970
LOC103459939
Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
    
 0.970
LOC103471589
CD40 ligand; Belongs to the tumor necrosis factor family.
   
 
 0.955
cflar
Uncharacterized protein; Belongs to the peptidase C14A family.
    
 0.935
tnfrsf1a
Tumor necrosis factor receptor superfamily, member 1a.
    
 
 0.920
LOC103478932
Caspase 20, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
    
 0.886
LOC108167062
Uncharacterized protein; Belongs to the peptidase C14A family.
    
 0.886
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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