Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
tnfrsf21Tumor necrosis factor receptor superfamily, member 21. (690 aa)    
Predicted Functional Partners:
app
Amyloid beta (A4) precursor protein a.
    
 
 0.861
LOC103459816
Amyloid beta (A4) precursor protein b.
    
 
 0.861
tradd
Tnfrsf1a-associated via death domain.
    
 
 0.807
aplp2
Amyloid beta (A4) precursor-like protein 2.
    
 
 0.662
ENSPREP00000025233
BPTI/Kunitz inhibitor domain-containing protein.
    
 
 0.662
slc15a4
Solute carrier family 15 member 4.
      
 0.641
casp6
Caspase 6, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.
      
 0.603
aplp1
Amyloid beta (A4) precursor-like protein 1.
    
 
 0.595
pla2g4a
Phospholipase A2.
      
 0.592
LOC103480636
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase.
      
 0.587
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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