LOC103466877 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

LOC103466877

Mitogen-activated protein kinase. (364 aa)

Predicted Functional Partners:

LOC103464872

0.987

LOC103481589

0.981

CDC25B

0.973

tp53

0.972

mapkapk5

0.965

LOC103476173

0.961

rps6ka5

0.961

mef2c

0.959

ENSPREP00000002835

0.954

LOC103473175

0.950

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC25B	LOC103466877	ENSPREP00000010131	ENSPREP00000003114	Cell division cycle 25B.	Mitogen-activated protein kinase.	0.973
CDC25B	tp53	ENSPREP00000010131	ENSPREP00000019676	Cell division cycle 25B.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.552
ENSPREP00000002835	LOC103466877	ENSPREP00000002835	ENSPREP00000003114	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Mitogen-activated protein kinase.	0.954
ENSPREP00000002835	tp53	ENSPREP00000002835	ENSPREP00000019676	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.816
LOC103464872	LOC103466877	ENSPREP00000005554	ENSPREP00000003114	MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.987
LOC103464872	LOC103481589	ENSPREP00000005554	ENSPREP00000011025	MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 6.	0.687
LOC103464872	tp53	ENSPREP00000005554	ENSPREP00000019676	MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.436
LOC103466877	CDC25B	ENSPREP00000003114	ENSPREP00000010131	Mitogen-activated protein kinase.	Cell division cycle 25B.	0.973
LOC103466877	ENSPREP00000002835	ENSPREP00000003114	ENSPREP00000002835	Mitogen-activated protein kinase.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.954
LOC103466877	LOC103464872	ENSPREP00000003114	ENSPREP00000005554	Mitogen-activated protein kinase.	MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily.	0.987
LOC103466877	LOC103473175	ENSPREP00000003114	ENSPREP00000020371	Mitogen-activated protein kinase.	MADS-box domain-containing protein.	0.950
LOC103466877	LOC103476173	ENSPREP00000003114	ENSPREP00000008255	Mitogen-activated protein kinase.	Ribosomal protein S6 kinase.	0.961
LOC103466877	LOC103481589	ENSPREP00000003114	ENSPREP00000011025	Mitogen-activated protein kinase.	Mitogen-activated protein kinase kinase 6.	0.981
LOC103466877	mapkapk5	ENSPREP00000003114	ENSPREP00000021870	Mitogen-activated protein kinase.	MAPK activated protein kinase 5.	0.965
LOC103466877	mef2c	ENSPREP00000003114	ENSPREP00000006694	Mitogen-activated protein kinase.	Myocyte enhancer factor 2cb.	0.959
LOC103466877	rps6ka5	ENSPREP00000003114	ENSPREP00000020985	Mitogen-activated protein kinase.	Ribosomal protein S6 kinase.	0.961
LOC103466877	tp53	ENSPREP00000003114	ENSPREP00000019676	Mitogen-activated protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.972
LOC103473175	LOC103466877	ENSPREP00000020371	ENSPREP00000003114	MADS-box domain-containing protein.	Mitogen-activated protein kinase.	0.950
LOC103473175	mef2c	ENSPREP00000020371	ENSPREP00000006694	MADS-box domain-containing protein.	Myocyte enhancer factor 2cb.	0.902
LOC103476173	LOC103466877	ENSPREP00000008255	ENSPREP00000003114	Ribosomal protein S6 kinase.	Mitogen-activated protein kinase.	0.961