STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC103466877Mitogen-activated protein kinase. (364 aa)    
Predicted Functional Partners:
LOC103464872
MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily.
  
0.979
LOC103481589
Mitogen-activated protein kinase kinase 6.
  
 0.978
MAPKAPK3
MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.
  
0.971
LOC103465075
MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.
  
0.971
mapkapk5
MAPK activated protein kinase 5.
   
0.962
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.951
LOC103473175
MADS-box domain-containing protein.
   
 0.951
LOC103476173
Ribosomal protein S6 kinase.
   
0.949
rps6ka5
Ribosomal protein S6 kinase.
   
0.949
CDC42
Cell division cycle 42.
   
 0.941
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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