dct protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

dct

Dopachrome tautomerase. (528 aa)

Predicted Functional Partners:

tyrp1

0.924

LOC103469120

0.917

LOC103465526

0.737

oca2

0.701

pmel

0.656

LOC103465401

0.643

gpnmb

0.631

slc24a5

0.626

RAB38

0.619

asip

0.617

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103465401	dct	ENSPREP00000025838	ENSPREP00000003234	GLUCAGON domain-containing protein.	Dopachrome tautomerase.	0.643
LOC103465526	LOC103469120	ENSPREP00000031809	ENSPREP00000016199	Melanocyte inducing transcription factor a.	Tyrosinase-related protein 1b.	0.587
LOC103465526	dct	ENSPREP00000031809	ENSPREP00000003234	Melanocyte inducing transcription factor a.	Dopachrome tautomerase.	0.737
LOC103465526	pmel	ENSPREP00000031809	ENSPREP00000021188	Melanocyte inducing transcription factor a.	Premelanosome protein a.	0.475
LOC103465526	slc24a5	ENSPREP00000031809	ENSPREP00000016291	Melanocyte inducing transcription factor a.	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.453
LOC103465526	tyrp1	ENSPREP00000031809	ENSPREP00000027088	Melanocyte inducing transcription factor a.	Tyrosinase related protein 1.	0.551
LOC103469120	LOC103465526	ENSPREP00000016199	ENSPREP00000031809	Tyrosinase-related protein 1b.	Melanocyte inducing transcription factor a.	0.587
LOC103469120	asip	ENSPREP00000016199	ENSPREP00000023419	Tyrosinase-related protein 1b.	Agouti domain-containing protein.	0.429
LOC103469120	dct	ENSPREP00000016199	ENSPREP00000003234	Tyrosinase-related protein 1b.	Dopachrome tautomerase.	0.917
LOC103469120	oca2	ENSPREP00000016199	ENSPREP00000025459	Tyrosinase-related protein 1b.	Oculocutaneous albinism II.	0.700
LOC103469120	pmel	ENSPREP00000016199	ENSPREP00000021188	Tyrosinase-related protein 1b.	Premelanosome protein a.	0.698
LOC103469120	slc24a5	ENSPREP00000016199	ENSPREP00000016291	Tyrosinase-related protein 1b.	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.563
LOC103469120	tyrp1	ENSPREP00000016199	ENSPREP00000027088	Tyrosinase-related protein 1b.	Tyrosinase related protein 1.	0.911
RAB38	dct	ENSPREP00000030455	ENSPREP00000003234	RAB38, member RAS oncogene family.	Dopachrome tautomerase.	0.619
RAB38	tyrp1	ENSPREP00000030455	ENSPREP00000027088	RAB38, member RAS oncogene family.	Tyrosinase related protein 1.	0.506
asip	LOC103469120	ENSPREP00000023419	ENSPREP00000016199	Agouti domain-containing protein.	Tyrosinase-related protein 1b.	0.429
asip	dct	ENSPREP00000023419	ENSPREP00000003234	Agouti domain-containing protein.	Dopachrome tautomerase.	0.617
asip	oca2	ENSPREP00000023419	ENSPREP00000025459	Agouti domain-containing protein.	Oculocutaneous albinism II.	0.522
asip	slc24a5	ENSPREP00000023419	ENSPREP00000016291	Agouti domain-containing protein.	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.512
asip	tyrp1	ENSPREP00000023419	ENSPREP00000027088	Agouti domain-containing protein.	Tyrosinase related protein 1.	0.429

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.872

expected number of edges:

10

PPI enrichment p-value:

0.00363

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044772

Mitotic cell cycle phase transition

7 of 105

2.14

4.55

7.76e-11

GO:0000079

Regulation of cyclin-dependent protein serine/threonine kinase activity

6 of 72

2.24

4.33

7.98e-10

GO:1903047

Mitotic cell cycle process

9 of 402

1.67

3.29

7.76e-11

GO:0051301

Cell division

7 of 393

1.57

2.39

1.20e-07

GO:0051726

Regulation of cell cycle

8 of 702

1.37

1.98

1.14e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016538

Cyclin-dependent protein serine/threonine kinase regulator activity

5 of 52

2.3

3.51

9.84e-08

GO:0003688

DNA replication origin binding

2 of 13

2.5

1.06

0.0118

GO:0030234

Enzyme regulator activity

6 of 1134

1.04

0.78

0.0038

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000307

Cyclin-dependent protein kinase holoenzyme complex

5 of 40

2.41

4.0

1.35e-08

GO:0097124

Cyclin A2-CDK2 complex

2 of 3

3.14

1.81

0.00053

GO:0005813

Centrosome

4 of 419

1.3

0.9

0.0062

GO:0015630

Microtubule cytoskeleton

5 of 1092

0.98

0.64

0.0128

GO:0005634

Nucleus

10 of 6688

0.49

0.37

0.0062

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37288606

(2023) Cytoplasmic Polyadenylation Is an Ancestral Hallmark of Early Development in Animals.

4 of 15

2.74

3.77

9.20e-08

PMID:24742317

(2014) Comparative analysis of the gonadal transcriptomes of the all-female species Poecilia formosa and its maternal ancestor Poecilia mexicana.

2 of 10

2.62

1.23

0.0057

PMID:24886435

(2014) Transcriptome assemblies for studying sex-biased gene expression in the guppy, Poecilia reticulata.

2 of 26

2.2

0.9

0.0216

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7892

Cyclin-dependent protein serine/threonine kinase regulator activity, and Cyclin-dependent protein kinase activity

6 of 49

2.41

4.71

3.34e-10

CL:7953

Mixed, incl. G2/M DNA replication checkpoint, and Positive regulation of meiotic cell cycle phase transition

4 of 11

2.88

4.08

2.82e-08

CL:7890

Mixed, incl. Mitotic cell cycle phase transition, and Mitotic sister chromatid segregation

7 of 163

1.95

3.79

8.91e-10

CL:7246

DNA replication origin binding, and MCM domain

3 of 14

2.65

2.43

3.11e-05

CL:7900

G2 Phase, and Cyclin-dependent kinase inhibitor

2 of 5

2.92

1.53

0.0017

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04110

Cell cycle

7 of 120

2.08

4.77

7.42e-12

pret04914

Progesterone-mediated oocyte maturation

4 of 88

1.98

2.45

6.58e-06

pret04218

Cellular senescence

3 of 178

1.54

1.09

0.0042

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-69273

Cyclin A/B1/B2 associated events during G2/M transition

7 of 36

2.61

6.96

1.36e-14

MAP-69478

G2/M DNA replication checkpoint

4 of 7

3.07

4.74

1.98e-09

MAP-69481

G2/M Checkpoints

8 of 189

1.94

4.59

1.41e-12

MAP-69620

Cell Cycle Checkpoints

10 of 344

1.78

4.42

1.26e-14

MAP-2995383

Initiation of Nuclear Envelope (NE) Reformation

4 of 19

2.64

3.94

3.54e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0097124

Cyclin A2-CDK2 complex

3 of 4

3.19

2.95

4.43e-06

GOCC:0000307

Cyclin-dependent protein kinase holoenzyme complex

4 of 37

2.35

2.77

4.43e-06

GOCC:0000808

Origin recognition complex

2 of 7

2.77

1.48

0.0020

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0195

Cyclin

5 of 33

2.5

4.51

1.48e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004367

Cyclin, C-terminal domain

5 of 16

2.81

4.75

1.28e-09

IPR039361

Cyclin

5 of 20

2.72

4.64

1.66e-09

IPR006671

Cyclin, N-terminal

5 of 35

2.47

4.04

1.37e-08

IPR013763

Cyclin-like domain

5 of 37

2.45

4.02

1.37e-08

IPR036915

Cyclin-like superfamily

5 of 47

2.34

3.76

3.24e-08

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00385

Domain present in cyclins, TFIIB and Retinoblastoma

5 of 41

2.4

4.06

9.36e-09

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About