RNF5 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

RNF5

Ring finger protein 5. (210 aa)

Predicted Functional Partners:

derl1

0.938

rnf185

0.903

cftr

0.899

sel1l

0.856

tmub1

0.855

LOC103469761

0.841

LOC103476975

0.841

tmem259

0.790

sting1

0.778

rps27a

0.734

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103469761	RNF5	ENSPREP00000026069	ENSPREP00000003402	Cholesterol 25-hydroxylase like 3.	Ring finger protein 5.	0.841
LOC103469761	cftr	ENSPREP00000026069	ENSPREP00000003668	Cholesterol 25-hydroxylase like 3.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.605
LOC103469761	derl1	ENSPREP00000026069	ENSPREP00000020837	Cholesterol 25-hydroxylase like 3.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.702
LOC103469761	rnf185	ENSPREP00000026069	ENSPREP00000017333	Cholesterol 25-hydroxylase like 3.	Ring finger protein 185.	0.841
LOC103469761	rps27a	ENSPREP00000026069	ENSPREP00000018427	Cholesterol 25-hydroxylase like 3.	Ribosomal protein S27a.	0.629
LOC103469761	sel1l	ENSPREP00000026069	ENSPREP00000019588	Cholesterol 25-hydroxylase like 3.	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.	0.715
LOC103469761	tmem259	ENSPREP00000026069	ENSPREP00000008526	Cholesterol 25-hydroxylase like 3.	Transmembrane protein 259.	0.515
LOC103469761	tmub1	ENSPREP00000026069	ENSPREP00000001883	Cholesterol 25-hydroxylase like 3.	Transmembrane and ubiquitin-like domain containing 1.	0.905
LOC103476975	RNF5	ENSPREP00000032103	ENSPREP00000003402	ER lipid raft associated 1.	Ring finger protein 5.	0.841
LOC103476975	cftr	ENSPREP00000032103	ENSPREP00000003668	ER lipid raft associated 1.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.605
LOC103476975	derl1	ENSPREP00000032103	ENSPREP00000020837	ER lipid raft associated 1.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.702
LOC103476975	rnf185	ENSPREP00000032103	ENSPREP00000017333	ER lipid raft associated 1.	Ring finger protein 185.	0.841
LOC103476975	rps27a	ENSPREP00000032103	ENSPREP00000018427	ER lipid raft associated 1.	Ribosomal protein S27a.	0.629
LOC103476975	sel1l	ENSPREP00000032103	ENSPREP00000019588	ER lipid raft associated 1.	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.	0.715
LOC103476975	tmem259	ENSPREP00000032103	ENSPREP00000008526	ER lipid raft associated 1.	Transmembrane protein 259.	0.515
LOC103476975	tmub1	ENSPREP00000032103	ENSPREP00000001883	ER lipid raft associated 1.	Transmembrane and ubiquitin-like domain containing 1.	0.905
RNF5	LOC103469761	ENSPREP00000003402	ENSPREP00000026069	Ring finger protein 5.	Cholesterol 25-hydroxylase like 3.	0.841
RNF5	LOC103476975	ENSPREP00000003402	ENSPREP00000032103	Ring finger protein 5.	ER lipid raft associated 1.	0.841
RNF5	cftr	ENSPREP00000003402	ENSPREP00000003668	Ring finger protein 5.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.899
RNF5	derl1	ENSPREP00000003402	ENSPREP00000020837	Ring finger protein 5.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.938