tnn protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

tnn

Tenascin N. (845 aa)

Predicted Functional Partners:

LOC103471589

0.711

svep1

0.648

LOC103458922

0.648

acan

0.571

ENSPREP00000026524

0.571

ENSPREP00000018724

0.529

LOC103477609

0.529

LOC103472829

0.529

ncan

0.513

LOC103460961

0.492

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000018724	ENSPREP00000026524	ENSPREP00000018724	ENSPREP00000026524	Uncharacterized protein.	Uncharacterized protein.	0.434
ENSPREP00000018724	LOC103472829	ENSPREP00000018724	ENSPREP00000032287	Uncharacterized protein.	Uncharacterized protein.	0.892
ENSPREP00000018724	acan	ENSPREP00000018724	ENSPREP00000008913	Uncharacterized protein.	Aggrecan b.	0.434
ENSPREP00000018724	ncan	ENSPREP00000018724	ENSPREP00000010106	Uncharacterized protein.	Neurocan b.	0.547
ENSPREP00000018724	tnn	ENSPREP00000018724	ENSPREP00000003451	Uncharacterized protein.	Tenascin N.	0.529
ENSPREP00000026524	ENSPREP00000018724	ENSPREP00000026524	ENSPREP00000018724	Uncharacterized protein.	Uncharacterized protein.	0.434
ENSPREP00000026524	LOC103472829	ENSPREP00000026524	ENSPREP00000032287	Uncharacterized protein.	Uncharacterized protein.	0.940
ENSPREP00000026524	LOC103477609	ENSPREP00000026524	ENSPREP00000027593	Uncharacterized protein.	Brevican.	0.434
ENSPREP00000026524	ncan	ENSPREP00000026524	ENSPREP00000010106	Uncharacterized protein.	Neurocan b.	0.571
ENSPREP00000026524	tnn	ENSPREP00000026524	ENSPREP00000003451	Uncharacterized protein.	Tenascin N.	0.571
LOC103458922	tnn	ENSPREP00000022023	ENSPREP00000003451	Si:dkey-21a6.5.	Tenascin N.	0.648
LOC103460961	tnn	ENSPREP00000018238	ENSPREP00000003451	Integrin beta.	Tenascin N.	0.492
LOC103471589	tnn	ENSPREP00000015614	ENSPREP00000003451	CD40 ligand; Belongs to the tumor necrosis factor family.	Tenascin N.	0.711
LOC103472829	ENSPREP00000018724	ENSPREP00000032287	ENSPREP00000018724	Uncharacterized protein.	Uncharacterized protein.	0.892
LOC103472829	ENSPREP00000026524	ENSPREP00000032287	ENSPREP00000026524	Uncharacterized protein.	Uncharacterized protein.	0.940
LOC103472829	acan	ENSPREP00000032287	ENSPREP00000008913	Uncharacterized protein.	Aggrecan b.	0.434
LOC103472829	ncan	ENSPREP00000032287	ENSPREP00000010106	Uncharacterized protein.	Neurocan b.	0.547
LOC103472829	tnn	ENSPREP00000032287	ENSPREP00000003451	Uncharacterized protein.	Tenascin N.	0.529
LOC103477609	ENSPREP00000026524	ENSPREP00000027593	ENSPREP00000026524	Brevican.	Uncharacterized protein.	0.434
LOC103477609	acan	ENSPREP00000027593	ENSPREP00000008913	Brevican.	Aggrecan b.	0.434

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.919

expected number of edges:

10

PPI enrichment p-value:

5.16e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006696

Ergosterol biosynthetic process

8 of 23

2.06

4.77

4.99e-12

GO:0008299

Isoprenoid biosynthetic process

6 of 14

2.15

4.17

9.02e-10

GO:0019287

Isopentenyl diphosphate biosynthetic process, mevalonate pathway

4 of 4

2.52

3.35

4.07e-07

GO:0006721

Terpenoid metabolic process

4 of 7

2.28

2.94

1.63e-06

GO:0045338

Farnesyl diphosphate metabolic process

3 of 6

2.22

2.0

0.00014

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4427

Ergosterol metabolic process

7 of 17

2.13

4.61

4.79e-11

CL:4451

Isopentenyl diphosphate biosynthetic process, mevalonate pathway

4 of 5

2.42

3.2

6.74e-07

CL:4429

Steroid biosynthesis

3 of 11

1.95

1.57

0.00075

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00900

Terpenoid backbone biosynthesis

5 of 22

1.88

2.68

8.45e-07

map00100

Steroid biosynthesis

3 of 14

1.85

1.57

0.00057

map01110

Biosynthesis of secondary metabolites

8 of 204

1.11

1.33

1.02e-06

map01100

Metabolic pathways

8 of 639

0.62

0.47

0.0029

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-191273

Cholesterol biosynthesis

6 of 18

2.04

3.55

1.45e-08

MAP-8957322

Metabolism of steroids

6 of 37

1.73

2.59

3.22e-07

MAP-556833

Metabolism of lipids

7 of 130

1.25

1.48

6.84e-06

MAP-1430728

Metabolism

7 of 484

0.68

0.42

0.0303

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0753

Steroid metabolism

3 of 6

2.22

1.82

0.00033

KW-0752

Steroid biosynthesis

3 of 6

2.22

1.82

0.00033

KW-0756

Sterol biosynthesis

2 of 5

2.12

1.15

0.0068

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00288

GHMP kinases N terminal domain

3 of 3

2.52

2.04

0.00016

PF08544

GHMP kinases C terminal

2 of 2

2.52

1.1

0.0097

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006204

GHMP kinase N-terminal domain

3 of 3

2.52

1.75

0.00059

IPR014721

Ribosomal protein S5 domain 2-type fold, subgroup

3 of 17

1.77

0.91

0.0163

IPR036554

GHMP kinase, C-terminal domain superfamily

2 of 2

2.52

0.89

0.0238

IPR013750

GHMP kinase, C-terminal domain

2 of 2

2.52

0.89

0.0238

IPR020568

Ribosomal protein S5 domain 2-type fold

3 of 24

1.62

0.8

0.0238

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