Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
aireAutoimmune regulator. (496 aa)    
Predicted Functional Partners:
rbbp4
Retinoblastoma binding protein 4.
   
 0.838
RBBP7
RB binding protein 7, chromatin remodeling factor.
   
 0.838
kdm1a
Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.
   
 0.825
gatad2b
GATA zinc finger domain containing 2B.
   
 0.772
LOC103463694
GATA zinc finger domain containing 2Ab.
   
 0.759
LOC103479433
Uncharacterized protein.
   
 0.759
LOC103463654
Methyl-CpG binding domain protein 3a.
    
 0.751
LOC103460256
Methyl-CpG binding domain protein 2.
    
 0.751
LOC103479450
Uncharacterized protein.
    
 0.751
LOC103480197
GATA-type domain-containing protein.
   
 0.738
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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