STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aireAutoimmune regulator. (496 aa)    
Predicted Functional Partners:
rbbp4
Retinoblastoma binding protein 4.
   
 0.806
RBBP7
RB binding protein 7, chromatin remodeling factor.
   
 0.786
Arid4a
Tudor domain-containing protein.
    
 0.736
arid4b
Translocase of outer mitochondrial membrane 20.
    
 0.736
LOC103463694
GATA zinc finger domain containing 2Ab.
   
 0.712
LOC103479433
Uncharacterized protein.
   
 0.712
gatad2b
GATA zinc finger domain containing 2B.
   
 0.712
LOC103463654
Methyl-CpG binding domain protein 3a.
    
 0.709
LOC103460256
Methyl-CpG binding domain protein 2.
    
 0.709
kdm1a
Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.
   
 0.703
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.