LOC103458086 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Score

LOC103458086

acidPPc domain-containing protein. (453 aa)

Predicted Functional Partners:

sgpl1

0.970

SPHK1

0.940

kdsr

0.929

asah1

0.927

acer3

0.927

LOC103482088

0.927

acer2

0.919

cers6

0.919

cers5

0.919

CERS5

0.919

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CERS5	LOC103458086	ENSPREP00000023281	ENSPREP00000003705	Ceramide synthase 5.	acidPPc domain-containing protein.	0.919
CERS5	SPHK1	ENSPREP00000023281	ENSPREP00000023952	Ceramide synthase 5.	Sphingosine kinase 1.	0.916
CERS5	cers5	ENSPREP00000023281	ENSPREP00000016028	Ceramide synthase 5.	Ceramide synthase 5.	0.901
CERS5	cers6	ENSPREP00000023281	ENSPREP00000010628	Ceramide synthase 5.	Ceramide synthase 6.	0.902
CERS5	kdsr	ENSPREP00000023281	ENSPREP00000006154	Ceramide synthase 5.	3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.936
LOC103458086	CERS5	ENSPREP00000003705	ENSPREP00000023281	acidPPc domain-containing protein.	Ceramide synthase 5.	0.919
LOC103458086	LOC103482088	ENSPREP00000003705	ENSPREP00000024304	acidPPc domain-containing protein.	Neutral ceramidase.	0.927
LOC103458086	SPHK1	ENSPREP00000003705	ENSPREP00000023952	acidPPc domain-containing protein.	Sphingosine kinase 1.	0.940
LOC103458086	acer2	ENSPREP00000003705	ENSPREP00000006494	acidPPc domain-containing protein.	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	0.919
LOC103458086	acer3	ENSPREP00000003705	ENSPREP00000015656	acidPPc domain-containing protein.	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	0.927
LOC103458086	asah1	ENSPREP00000003705	ENSPREP00000000094	acidPPc domain-containing protein.	N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family.	0.927
LOC103458086	cers5	ENSPREP00000003705	ENSPREP00000016028	acidPPc domain-containing protein.	Ceramide synthase 5.	0.919
LOC103458086	cers6	ENSPREP00000003705	ENSPREP00000010628	acidPPc domain-containing protein.	Ceramide synthase 6.	0.919
LOC103458086	kdsr	ENSPREP00000003705	ENSPREP00000006154	acidPPc domain-containing protein.	3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.929
LOC103458086	sgpl1	ENSPREP00000003705	ENSPREP00000003210	acidPPc domain-containing protein.	Sphingosine-1-phosphate lyase 1.	0.970
LOC103482088	LOC103458086	ENSPREP00000024304	ENSPREP00000003705	Neutral ceramidase.	acidPPc domain-containing protein.	0.927
LOC103482088	SPHK1	ENSPREP00000024304	ENSPREP00000023952	Neutral ceramidase.	Sphingosine kinase 1.	0.953
LOC103482088	acer2	ENSPREP00000024304	ENSPREP00000006494	Neutral ceramidase.	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	0.963
LOC103482088	acer3	ENSPREP00000024304	ENSPREP00000015656	Neutral ceramidase.	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	0.560
LOC103482088	asah1	ENSPREP00000024304	ENSPREP00000000094	Neutral ceramidase.	N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family.	0.952

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Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.962

expected number of edges:

21

PPI enrichment p-value:

2.12e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000398

mRNA splicing, via spliceosome

7 of 114

1.93

3.7

1.29e-09

GO:0000387

Spliceosomal snRNP assembly

4 of 13

2.63

3.67

1.22e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

8 of 570

1.29

1.69

7.21e-07

GO:0017069

snRNA binding

2 of 10

2.45

1.03

0.0129

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005685

U1 snRNP

6 of 9

2.97

7.13

4.16e-14

GO:0005686

U2 snRNP

6 of 18

2.67

6.38

3.72e-13

GO:0071011

Precatalytic spliceosome

6 of 20

2.62

6.24

5.45e-13

GO:0097525

Spliceosomal snRNP complex

7 of 41

2.38

6.11

1.32e-13

GO:0005682

U5 snRNP

5 of 10

2.84

5.76

1.42e-11

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8704

U2 snRNP, and snRNA binding

8 of 19

2.77

8.8

5.04e-18

CL:8701

Small nuclear ribonucleoprotein complex, and snRNA binding

9 of 35

2.55

8.7

6.73e-19

CL:8706

U1 snRNP, and KH domain

6 of 10

2.92

7.1

4.17e-14

CL:8709

SLBP independent Processing of Histone Pre-mRNAs

4 of 5

3.05

4.63

3.12e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

9 of 158

1.9

4.93

1.25e-14

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-111367

SLBP independent Processing of Histone Pre-mRNAs

5 of 6

3.07

6.0

8.13e-12

MAP-77588

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

5 of 7

3.0

5.92

1.04e-11

MAP-75067

Processing of Capped Intronless Pre-mRNA

5 of 22

2.5

4.67

7.06e-10

MAP-72172

mRNA Splicing

9 of 177

1.85

4.47

2.02e-13

MAP-73856

RNA Polymerase II Transcription Termination

5 of 50

2.14

3.62

2.26e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0097525

Spliceosomal snRNP complex

6 of 26

2.51

5.52

9.83e-12

GOCC:0005689

U12-type spliceosomal complex

5 of 11

2.8

5.46

4.87e-11

GOCC:0005682

U5 snRNP

5 of 11

2.8

5.46

4.87e-11

GOCC:0005687

U4 snRNP

4 of 7

2.9

4.45

5.77e-09

GOCC:1990904

Ribonucleoprotein complex

9 of 258

1.69

3.57

5.83e-12

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0508

mRNA splicing

6 of 16

2.72

6.41

4.24e-13

KW-0687

Ribonucleoprotein

6 of 75

2.05

4.05

6.04e-10

KW-0747

Spliceosome

3 of 10

2.62

2.92

3.50e-06

KW-0539

Nucleus

6 of 297

1.45

1.95

1.34e-06

KW-0694

RNA-binding

4 of 140

1.6

1.7

8.71e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR047575

Sm domain

6 of 17

2.69

5.75

8.59e-12

IPR001163

Sm domain, eukaryotic/archaea-type

6 of 17

2.69

5.75

8.59e-12

IPR010920

LSM domain superfamily

6 of 21

2.6

5.66

8.59e-12

IPR034099

Small nuclear ribonucleoprotein Sm D3

2 of 2

3.14

1.45

0.0024

IPR027141

Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3

2 of 3

2.97

1.39

0.0031

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00651

snRNP Sm proteins

6 of 17

2.69

6.22

8.97e-13

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