Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (387 aa)    
Predicted Functional Partners:
ccnh
Cyclin H; Belongs to the cyclin family.
   
 0.996
mnat1
CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.
   
 0.973
ercc3
Excision repair cross-complementation group 3.
    
 0.962
LOC103470674
General transcription factor IIH subunit.
   
 0.960
gtf2h3
General transcription factor IIH, polypeptide 3.
   
 0.960
gtf2h4
General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.
    
 0.953
cdk1
Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.
  
0.952
cdk2
Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.
  
0.952
gtf2h5
General transcription factor IIH, polypeptide 5.
    
 0.935
ercc2
Excision repair cross-complementation group 2.
    
 0.924
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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