Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ENSPREP00000003814RING-type domain-containing protein. (204 aa)    
Predicted Functional Partners:
DTX1
Deltex E3 ubiquitin ligase 1.
      
 0.603
dhx58
DEXH (Asp-Glu-X-His) box polypeptide 58.
   
 0.593
ifih1
Interferon induced with helicase C domain 1.
   
 0.589
casp6
Caspase 6, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.
   
 0.566
irf5
Interferon regulatory factor 5.
    
 0.553
mavs
CARD_2 domain-containing protein.
   
 0.502
LOC103481249
Interferon regulatory factor 3.
   
 0.497
tap1
Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP).
   
 
 0.430
myd88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
   
 0.409
tlr3
Toll-like receptor 3; Belongs to the Toll-like receptor family.
    
 0.402
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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