STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
rfflRing finger and FYVE-like domain containing E3 ubiquitin protein ligase. (342 aa)    
Predicted Functional Partners:
RNF207
Ring finger protein 207a.
      
 0.728
LOC103464127
Proline rich Gla (G-carboxyglutamic acid) 1.
      
 0.670
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
  0.650
efcab7
EF-hand calcium binding domain 7.
    
   0.561
rps27a
Ribosomal protein S27a.
     
  0.541
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
     
  0.524
LOC103467304
Uncharacterized protein; Belongs to the CTL (choline transporter-like) family.
      
 0.497
LOC103471777
Solute carrier family 44 member 1b; Belongs to the CTL (choline transporter-like) family.
      
 0.497
gins3
GINS complex subunit 3.
      
 0.495
LOC103471523
Zgc:101583.
      
 0.409
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.