LOC103471015 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

LOC103471015

Cyclic nucleotide-binding domain-containing protein. (663 aa)

Predicted Functional Partners:

LOC103482329

0.709

LOC103482304

0.708

ENSPREP00000001490

0.700

cngb1

0.698

guca1b

0.533

cnga4

0.491

guca1a

0.488

exoc4

0.455

gnat1

0.433

LOC103467179

0.433

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000001490	LOC103467179	ENSPREP00000001490	ENSPREP00000021938	Si:dkey-44k1.5.	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	0.514
ENSPREP00000001490	LOC103471015	ENSPREP00000001490	ENSPREP00000004024	Si:dkey-44k1.5.	Cyclic nucleotide-binding domain-containing protein.	0.700
ENSPREP00000001490	cnga4	ENSPREP00000001490	ENSPREP00000005649	Si:dkey-44k1.5.	Cyclic nucleotide gated channel subunit alpha 4.	0.711
ENSPREP00000001490	gnat1	ENSPREP00000001490	ENSPREP00000005925	Si:dkey-44k1.5.	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1.	0.514
ENSPREP00000001490	guca1a	ENSPREP00000001490	ENSPREP00000032624	Si:dkey-44k1.5.	Guanylate cyclase activator 1A.	0.505
ENSPREP00000001490	guca1b	ENSPREP00000001490	ENSPREP00000007120	Si:dkey-44k1.5.	Guanylate cyclase activator 1B.	0.527
LOC103467179	ENSPREP00000001490	ENSPREP00000021938	ENSPREP00000001490	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	Si:dkey-44k1.5.	0.514
LOC103467179	LOC103471015	ENSPREP00000021938	ENSPREP00000004024	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	Cyclic nucleotide-binding domain-containing protein.	0.433
LOC103467179	LOC103482304	ENSPREP00000021938	ENSPREP00000016006	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	Cyclic nucleotide gated channel beta 3, tandem duplicate 2.	0.562
LOC103467179	LOC103482329	ENSPREP00000021938	ENSPREP00000015963	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	Cyclic nucleotide gated channel beta 3, tandem duplicate 1.	0.562
LOC103467179	cnga4	ENSPREP00000021938	ENSPREP00000005649	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	Cyclic nucleotide gated channel subunit alpha 4.	0.433
LOC103467179	cngb1	ENSPREP00000021938	ENSPREP00000013025	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	Cyclic nucleotide gated channel beta 1a.	0.578
LOC103467179	gnat1	ENSPREP00000021938	ENSPREP00000005925	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1.	0.935
LOC103467179	guca1a	ENSPREP00000021938	ENSPREP00000032624	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	Guanylate cyclase activator 1A.	0.683
LOC103467179	guca1b	ENSPREP00000021938	ENSPREP00000007120	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	Guanylate cyclase activator 1B.	0.427
LOC103471015	ENSPREP00000001490	ENSPREP00000004024	ENSPREP00000001490	Cyclic nucleotide-binding domain-containing protein.	Si:dkey-44k1.5.	0.700
LOC103471015	LOC103467179	ENSPREP00000004024	ENSPREP00000021938	Cyclic nucleotide-binding domain-containing protein.	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	0.433
LOC103471015	LOC103482304	ENSPREP00000004024	ENSPREP00000016006	Cyclic nucleotide-binding domain-containing protein.	Cyclic nucleotide gated channel beta 3, tandem duplicate 2.	0.708
LOC103471015	LOC103482329	ENSPREP00000004024	ENSPREP00000015963	Cyclic nucleotide-binding domain-containing protein.	Cyclic nucleotide gated channel beta 3, tandem duplicate 1.	0.709
LOC103471015	cnga4	ENSPREP00000004024	ENSPREP00000005649	Cyclic nucleotide-binding domain-containing protein.	Cyclic nucleotide gated channel subunit alpha 4.	0.491

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Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.889

expected number of edges:

13

PPI enrichment p-value:

0.132

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006259

DNA metabolic process

7 of 96

1.41

1.81

2.98e-06

GO:0006281

DNA repair

5 of 43

1.61

1.75

6.67e-05

GO:0006310

DNA recombination

4 of 29

1.69

1.66

0.00019

GO:0006260

DNA replication

4 of 32

1.64

1.61

0.00021

GO:0071103

DNA conformation change

3 of 13

1.91

1.52

0.00087

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003697

Single-stranded DNA binding

3 of 6

2.25

1.73

0.00052

GO:0140097

Catalytic activity, acting on DNA

5 of 50

1.55

1.57

0.00015

GO:0003917

DNA topoisomerase type I (single strand cut, ATP-independent) activity

2 of 2

2.55

1.15

0.0080

GO:0003677

DNA binding

6 of 339

0.79

0.52

0.0155

GO:0003676

Nucleic acid binding

7 of 468

0.72

0.49

0.0122

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005694

Chromosome

3 of 21

1.7

1.13

0.0046

GO:0009295

Nucleoid

3 of 33

1.51

0.97

0.0079

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:604

ATP-dependent activity, acting on DNA, and DNA/RNA polymerase superfamily

4 of 5

2.45

3.07

1.33e-06

CL:600

DNA replication, and SOS response

6 of 38

1.75

2.54

5.87e-07

CL:1721

Mixed, incl. Phasin, and Thioredoxin

2 of 6

2.07

0.81

0.0301

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

aka03440

Homologous recombination

4 of 18

1.89

2.14

2.76e-05

aka03030

DNA replication

3 of 15

1.85

1.52

0.00075

aka03430

Mismatch repair

2 of 12

1.77

0.83

0.0241

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009295

Nucleoid

3 of 15

1.85

1.22

0.0037

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0234

DNA repair

3 of 19

1.75

1.13

0.0051

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00436

Single-strand binding protein family

2 of 2

2.55

0.9

0.0226

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