LOC103470404 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

Your Input:

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[Homology]

Score

LOC103470404

Cardiomyopathy associated 5. (1606 aa)

Predicted Functional Partners:

homez

0.661

trappc12

0.646

smg6

0.646

cnot1

0.646

pask

0.563

myrf

0.553

myot

0.534

nrap

0.511

LOC103476706

0.480

dtnbp1

0.479

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103470404	LOC103476706	ENSPREP00000004153	ENSPREP00000014247	Cardiomyopathy associated 5.	Coiled-coil serine-rich protein 2a.	0.480
LOC103470404	cnot1	ENSPREP00000004153	ENSPREP00000027855	Cardiomyopathy associated 5.	CCR4-NOT transcription complex, subunit 1.	0.646
LOC103470404	dtnbp1	ENSPREP00000004153	ENSPREP00000012354	Cardiomyopathy associated 5.	Dystrobrevin binding protein 1b.	0.479
LOC103470404	homez	ENSPREP00000004153	ENSPREP00000032408	Cardiomyopathy associated 5.	Homeobox and leucine zipper encoding a.	0.661
LOC103470404	myot	ENSPREP00000004153	ENSPREP00000004461	Cardiomyopathy associated 5.	Myotilin.	0.534
LOC103470404	myrf	ENSPREP00000004153	ENSPREP00000017004	Cardiomyopathy associated 5.	Myelin regulatory factor.	0.553
LOC103470404	nrap	ENSPREP00000004153	ENSPREP00000033274	Cardiomyopathy associated 5.	Nebulin-related anchoring protein.	0.511
LOC103470404	pask	ENSPREP00000004153	ENSPREP00000024454	Cardiomyopathy associated 5.	PAS domain containing serine/threonine kinase.	0.563
LOC103470404	smg6	ENSPREP00000004153	ENSPREP00000014902	Cardiomyopathy associated 5.	SMG6 nonsense mediated mRNA decay factor.	0.646
LOC103470404	trappc12	ENSPREP00000004153	ENSPREP00000004768	Cardiomyopathy associated 5.	Trafficking protein particle complex 12.	0.646
LOC103476706	LOC103470404	ENSPREP00000014247	ENSPREP00000004153	Coiled-coil serine-rich protein 2a.	Cardiomyopathy associated 5.	0.480
cnot1	LOC103470404	ENSPREP00000027855	ENSPREP00000004153	CCR4-NOT transcription complex, subunit 1.	Cardiomyopathy associated 5.	0.646
cnot1	homez	ENSPREP00000027855	ENSPREP00000032408	CCR4-NOT transcription complex, subunit 1.	Homeobox and leucine zipper encoding a.	0.633
cnot1	myrf	ENSPREP00000027855	ENSPREP00000017004	CCR4-NOT transcription complex, subunit 1.	Myelin regulatory factor.	0.526
cnot1	smg6	ENSPREP00000027855	ENSPREP00000014902	CCR4-NOT transcription complex, subunit 1.	SMG6 nonsense mediated mRNA decay factor.	0.649
cnot1	trappc12	ENSPREP00000027855	ENSPREP00000004768	CCR4-NOT transcription complex, subunit 1.	Trafficking protein particle complex 12.	0.644
dtnbp1	LOC103470404	ENSPREP00000012354	ENSPREP00000004153	Dystrobrevin binding protein 1b.	Cardiomyopathy associated 5.	0.479
homez	LOC103470404	ENSPREP00000032408	ENSPREP00000004153	Homeobox and leucine zipper encoding a.	Cardiomyopathy associated 5.	0.661
homez	cnot1	ENSPREP00000032408	ENSPREP00000027855	Homeobox and leucine zipper encoding a.	CCR4-NOT transcription complex, subunit 1.	0.633
homez	myrf	ENSPREP00000032408	ENSPREP00000017004	Homeobox and leucine zipper encoding a.	Myelin regulatory factor.	0.525

page 1 of 3

Network Stats

number of nodes:

10

number of edges:

21

average node degree:

4.2

avg. local clustering coefficient:

0.873

expected number of edges:

9

PPI enrichment p-value:

0.000652

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0040019

Positive regulation of embryonic development

2 of 6

2.88

0.81

0.0391

GO:0045039

Protein insertion into mitochondrial inner membrane

2 of 8

2.76

0.8

0.0391

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005743

Mitochondrial inner membrane

4 of 419

1.34

0.72

0.0279

GO:0098798

Mitochondrial protein-containing complex

3 of 267

1.41

0.65

0.0463

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6513

Mixed, incl. Tim10-like, and Mitochondrial intermembrane space import and assembly protein 40

4 of 17

2.73

3.46

5.49e-07

CL:6519

TIM22 mitochondrial import inner membrane insertion complex, and Tim10-like

3 of 5

3.14

2.98

5.61e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

3 of 47

2.16

1.47

0.0019

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 5

2.96

1.46

0.0028

GOCC:0098798

Mitochondrial protein complex

4 of 228

1.6

1.2

0.0028

GOCC:0005740

Mitochondrial envelope

4 of 383

1.38

1.05

0.0034

GOCC:0031967

Organelle envelope

5 of 547

1.32

1.03

0.0028

GOCC:0071013

Catalytic step 2 spliceosome

2 of 37

2.09

0.92

0.0215

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

2 of 20

2.36

1.05

0.0132

KW-0496

Mitochondrion

3 of 160

1.63

0.94

0.0132

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10312

Conserved mid region of cactin

2 of 2

3.36

1.51

0.0023

PF04621

PEA3 subfamily ETS-domain transcription factor N terminal domain

2 of 4

3.06

1.45

0.0029

PF02953

Tim10/DDP family zinc finger

2 of 6

2.88

1.39

0.0036

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019134

Splicing factor Cactin, C-terminal

2 of 2

3.36

1.23

0.0073

IPR018816

Splicing factor cactin, central domain

2 of 2

3.36

1.23

0.0073

IPR006715

PEA3-type ETS-domain transcription factor, N-terminal

2 of 4

3.06

1.22

0.0073

IPR035427

Tim10-like domain superfamily

2 of 6

2.88

1.18

0.0085

IPR004217

Tim10-like

2 of 6

2.88

1.18

0.0085

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01050

Cactus-binding C-terminus of cactin protein

2 of 3

3.18

1.65

0.0013

SM00413

Erythroblast transformation specific domain

2 of 32

2.15

0.8

0.0372

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