STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)    
Predicted Functional Partners:
ccnd1
Cyclin D1; Belongs to the cyclin family.
   
 0.996
LOC103466812
Cyclin D2, a; Belongs to the cyclin family.
   
 0.985
LOC103459164
Cyclin D2, b; Belongs to the cyclin family.
   
 0.985
cdkn2b
Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4).
    
 0.984
ENSPREP00000032744
Retinoblastoma 1.
   
 0.984
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.980
LOC103465183
Cyclin-dependent kinase inhibitor 1A.
   
 0.979
ENSPREP00000023356
Retinoblastoma-like 1 (p107).
   
 0.978
LOC103466787
Retinoblastoma-like 2 (p130).
   
 0.978
Ccnd3
Cyclin D3; Belongs to the cyclin family.
   
 0.974
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.