actn3 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

actn3

Actinin alpha 3b. (897 aa)

Predicted Functional Partners:

LOC103476717

0.900

ENSPREP00000018081

0.890

vcl

0.788

LOC103476978

0.788

LOC103459892

0.720

LOC103469495

0.720

camk2b

0.720

LOC103480087

0.720

LOC103461533

0.705

parva

0.658

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000018081	LOC103476717	ENSPREP00000018081	ENSPREP00000014912	PH_9 domain-containing protein.	Actinin, alpha 2b.	0.888
ENSPREP00000018081	actn3	ENSPREP00000018081	ENSPREP00000004223	PH_9 domain-containing protein.	Actinin alpha 3b.	0.890
LOC103459892	LOC103476717	ENSPREP00000004745	ENSPREP00000014912	Calcium/calmodulin-dependent protein kinase II alpha.	Actinin, alpha 2b.	0.720
LOC103459892	actn3	ENSPREP00000004745	ENSPREP00000004223	Calcium/calmodulin-dependent protein kinase II alpha.	Actinin alpha 3b.	0.720
LOC103461533	LOC103476717	ENSPREP00000018183	ENSPREP00000014912	Myosin, light chain 1, alkali; skeletal, fast.	Actinin, alpha 2b.	0.705
LOC103461533	LOC103476978	ENSPREP00000018183	ENSPREP00000032212	Myosin, light chain 1, alkali; skeletal, fast.	Vinculin a.	0.414
LOC103461533	actn3	ENSPREP00000018183	ENSPREP00000004223	Myosin, light chain 1, alkali; skeletal, fast.	Actinin alpha 3b.	0.705
LOC103461533	vcl	ENSPREP00000018183	ENSPREP00000004437	Myosin, light chain 1, alkali; skeletal, fast.	Vinculin b.	0.414
LOC103469495	LOC103476717	ENSPREP00000014488	ENSPREP00000014912	Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2.	Actinin, alpha 2b.	0.720
LOC103469495	actn3	ENSPREP00000014488	ENSPREP00000004223	Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2.	Actinin alpha 3b.	0.720
LOC103476717	ENSPREP00000018081	ENSPREP00000014912	ENSPREP00000018081	Actinin, alpha 2b.	PH_9 domain-containing protein.	0.888
LOC103476717	LOC103459892	ENSPREP00000014912	ENSPREP00000004745	Actinin, alpha 2b.	Calcium/calmodulin-dependent protein kinase II alpha.	0.720
LOC103476717	LOC103461533	ENSPREP00000014912	ENSPREP00000018183	Actinin, alpha 2b.	Myosin, light chain 1, alkali; skeletal, fast.	0.705
LOC103476717	LOC103469495	ENSPREP00000014912	ENSPREP00000014488	Actinin, alpha 2b.	Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2.	0.720
LOC103476717	LOC103476978	ENSPREP00000014912	ENSPREP00000032212	Actinin, alpha 2b.	Vinculin a.	0.788
LOC103476717	LOC103480087	ENSPREP00000014912	ENSPREP00000031947	Actinin, alpha 2b.	Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1; Belongs to the protein kinase superfamily.	0.720
LOC103476717	actn3	ENSPREP00000014912	ENSPREP00000004223	Actinin, alpha 2b.	Actinin alpha 3b.	0.900
LOC103476717	camk2b	ENSPREP00000014912	ENSPREP00000022701	Actinin, alpha 2b.	Calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2.	0.720
LOC103476717	parva	ENSPREP00000014912	ENSPREP00000002306	Actinin, alpha 2b.	Parvin, alpha a.	0.658
LOC103476717	vcl	ENSPREP00000014912	ENSPREP00000004437	Actinin, alpha 2b.	Vinculin b.	0.788