ENSPREP00000004255 protein (Poecilia reticulata)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

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gene co-occurrence

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Score

ENSPREP00000004255

ANK_REP_REGION domain-containing protein. (314 aa)

Predicted Functional Partners:

aplp1

0.676

sdhaf1

0.644

HLCS

0.549

LOC103479635

0.543

prodh2

0.542

themis2

0.528

TMEM43

0.522

fbxl5

0.522

bahd1

0.495

ift81

0.493

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000004255	HLCS	ENSPREP00000004255	ENSPREP00000024353	ANK_REP_REGION domain-containing protein.	Holocarboxylase synthetase.	0.549
ENSPREP00000004255	LOC103479635	ENSPREP00000004255	ENSPREP00000009477	ANK_REP_REGION domain-containing protein.	Death domain-containing protein.	0.543
ENSPREP00000004255	TMEM43	ENSPREP00000004255	ENSPREP00000008122	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.522
ENSPREP00000004255	aplp1	ENSPREP00000004255	ENSPREP00000005022	ANK_REP_REGION domain-containing protein.	Amyloid beta (A4) precursor-like protein 1.	0.676
ENSPREP00000004255	bahd1	ENSPREP00000004255	ENSPREP00000024499	ANK_REP_REGION domain-containing protein.	Bromo adjacent homology domain containing 1.	0.495
ENSPREP00000004255	fbxl5	ENSPREP00000004255	ENSPREP00000027490	ANK_REP_REGION domain-containing protein.	F-box and leucine-rich repeat protein 5.	0.522
ENSPREP00000004255	ift81	ENSPREP00000004255	ENSPREP00000024120	ANK_REP_REGION domain-containing protein.	Intraflagellar transport 81 homolog.	0.493
ENSPREP00000004255	prodh2	ENSPREP00000004255	ENSPREP00000034156	ANK_REP_REGION domain-containing protein.	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.	0.542
ENSPREP00000004255	sdhaf1	ENSPREP00000004255	ENSPREP00000026029	ANK_REP_REGION domain-containing protein.	Uncharacterized protein; Belongs to the complex I LYR family.	0.644
ENSPREP00000004255	themis2	ENSPREP00000004255	ENSPREP00000007474	ANK_REP_REGION domain-containing protein.	Thymocyte selection associated family member 2.	0.528
HLCS	ENSPREP00000004255	ENSPREP00000024353	ENSPREP00000004255	Holocarboxylase synthetase.	ANK_REP_REGION domain-containing protein.	0.549
HLCS	aplp1	ENSPREP00000024353	ENSPREP00000005022	Holocarboxylase synthetase.	Amyloid beta (A4) precursor-like protein 1.	0.645
HLCS	prodh2	ENSPREP00000024353	ENSPREP00000034156	Holocarboxylase synthetase.	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.	0.528
HLCS	sdhaf1	ENSPREP00000024353	ENSPREP00000026029	Holocarboxylase synthetase.	Uncharacterized protein; Belongs to the complex I LYR family.	0.640
LOC103479635	ENSPREP00000004255	ENSPREP00000009477	ENSPREP00000004255	Death domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.543
LOC103479635	TMEM43	ENSPREP00000009477	ENSPREP00000008122	Death domain-containing protein.	Uncharacterized protein.	0.495
LOC103479635	bahd1	ENSPREP00000009477	ENSPREP00000024499	Death domain-containing protein.	Bromo adjacent homology domain containing 1.	0.477
LOC103479635	fbxl5	ENSPREP00000009477	ENSPREP00000027490	Death domain-containing protein.	F-box and leucine-rich repeat protein 5.	0.495
LOC103479635	themis2	ENSPREP00000009477	ENSPREP00000007474	Death domain-containing protein.	Thymocyte selection associated family member 2.	0.504
TMEM43	ENSPREP00000004255	ENSPREP00000008122	ENSPREP00000004255	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.522

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Network Stats

Network Stats analysis is still ongoing, please wait ...

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000169

Regulation of peptidyl-cysteine S-nitrosylation

4 of 8

3.02

3.79

1.16e-07

GO:0098974

Postsynaptic actin cytoskeleton organization

4 of 15

2.74

3.41

4.54e-07

GO:0060307

Regulation of ventricular cardiac muscle cell membrane repolarization

4 of 15

2.74

3.41

4.54e-07

GO:1901385

Regulation of voltage-gated calcium channel activity

4 of 39

2.33

2.78

4.11e-06

GO:0002027

Regulation of heart rate

4 of 40

2.32

2.77

4.11e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050998

Nitric-oxide synthase binding

4 of 8

3.02

4.04

3.84e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016010

Dystrophin-associated glycoprotein complex

4 of 14

2.77

3.74

1.11e-07

GO:0002102

Podosome

4 of 18

2.66

3.66

1.33e-07

GO:0033017

Sarcoplasmic reticulum membrane

4 of 31

2.43

3.28

4.74e-07

GO:0030175

Filopodium

4 of 72

2.06

2.57

5.11e-06

GO:0030018

Z disc

4 of 102

1.91

2.24

1.61e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:36908

Mixed, incl. Dystrophin-associated glycoprotein complex, and EF hand

7 of 31

2.67

6.88

3.20e-14

CL:36910

EF hand, and Syntrophin

4 of 12

2.84

3.88

6.57e-08

CL:36947

Mixed, incl. Torsin 1/2, and Torsin-1A-interacting protein 1/2

3 of 10

2.79

2.56

1.97e-05

CL:36950

Nitric-oxide synthase binding, and Torsin 1/2

2 of 5

2.92

1.39

0.0031

CL:36912

Mixed, incl. EF hand, and Syntrophin, split Pleckstrin homology (PH) domain

2 of 7

2.77

1.28

0.0047

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000562

Heart

4 of 407

1.31

1.26

0.00028

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016010

Dystrophin-associated glycoprotein complex

5 of 24

2.64

4.6

1.60e-09

GOCC:0045202

Synapse

4 of 531

1.19

0.68

0.0232

GOCC:0016020

Membrane

9 of 5135

0.56

0.38

0.0197

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR015482

Syntrophin

4 of 4

3.32

4.32

1.44e-08

IPR041428

Syntrophin, split Pleckstrin homology (PH) domain

3 of 3

3.32

2.98

4.04e-06

IPR011993

PH-like domain superfamily

7 of 529

1.44

1.83

4.04e-06

IPR006020

PTB/PI domain

3 of 57

2.04

1.28

0.0035

IPR001478

PDZ domain

4 of 201

1.62

1.15

0.0035

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00462

Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain

3 of 39

2.2

1.64

0.00073

SM00233

Pleckstrin homology domain.

4 of 325

1.41

0.99

0.0050

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