Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hacd2Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (244 aa)    
Predicted Functional Partners:
tecr
Trans-2,3-enoyl-CoA reductase b.
   
 0.975
LOC103482281
Trans-2,3-enoyl-CoA reductase-like 2a.
   
 0.975
LOC103462728
Hydroxysteroid (17-beta) dehydrogenase 12b; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 0.958
LOC103465755
Hydroxysteroid (17-beta) dehydrogenase 12a; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 0.958
LOC103475782
Hydroxysteroid (20-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 0.958
LOC103475783
Hydroxysteroid (20-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 0.958
LOC103461005
S5A_REDUCTASE domain-containing protein.
   
 0.768
LOC103477318
Exportin 1 (CRM1 homolog, yeast) b.
    
 
 0.728
xpo1
Exportin 1 (CRM1 homolog, yeast) a.
    
 
 0.728
skp1
S-phase kinase-associated protein 1; Belongs to the SKP1 family.
    
 
 0.665
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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