LOC103475295 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

LOC103475295

Endothelin converting enzyme 2b. (773 aa)

Predicted Functional Partners:

edn1

0.772

LOC103472162

0.681

LOC103465492

0.583

agt

0.564

LOC103479378

0.525

LOC103471340

0.513

ENSPREP00000024835

0.449

dipk2a

0.400

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000024835	LOC103471340	ENSPREP00000024835	ENSPREP00000034313	END domain-containing protein.	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	0.723
ENSPREP00000024835	LOC103475295	ENSPREP00000024835	ENSPREP00000004357	END domain-containing protein.	Endothelin converting enzyme 2b.	0.449
ENSPREP00000024835	agt	ENSPREP00000024835	ENSPREP00000016816	END domain-containing protein.	Angiotensinogen; Belongs to the serpin family.	0.477
ENSPREP00000024835	edn1	ENSPREP00000024835	ENSPREP00000012837	END domain-containing protein.	Endothelin 1.	0.623
LOC103465492	LOC103471340	ENSPREP00000030717	ENSPREP00000034313	Uncharacterized protein.	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	0.986
LOC103465492	LOC103475295	ENSPREP00000030717	ENSPREP00000004357	Uncharacterized protein.	Endothelin converting enzyme 2b.	0.583
LOC103465492	agt	ENSPREP00000030717	ENSPREP00000016816	Uncharacterized protein.	Angiotensinogen; Belongs to the serpin family.	0.548
LOC103465492	edn1	ENSPREP00000030717	ENSPREP00000012837	Uncharacterized protein.	Endothelin 1.	0.967
LOC103471340	ENSPREP00000024835	ENSPREP00000034313	ENSPREP00000024835	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	END domain-containing protein.	0.723
LOC103471340	LOC103465492	ENSPREP00000034313	ENSPREP00000030717	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.986
LOC103471340	LOC103475295	ENSPREP00000034313	ENSPREP00000004357	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	Endothelin converting enzyme 2b.	0.513
LOC103471340	agt	ENSPREP00000034313	ENSPREP00000016816	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	Angiotensinogen; Belongs to the serpin family.	0.697
LOC103471340	edn1	ENSPREP00000034313	ENSPREP00000012837	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.998
LOC103472162	LOC103475295	ENSPREP00000029967	ENSPREP00000004357	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Endothelin converting enzyme 2b.	0.681
LOC103475295	ENSPREP00000024835	ENSPREP00000004357	ENSPREP00000024835	Endothelin converting enzyme 2b.	END domain-containing protein.	0.449
LOC103475295	LOC103465492	ENSPREP00000004357	ENSPREP00000030717	Endothelin converting enzyme 2b.	Uncharacterized protein.	0.583
LOC103475295	LOC103471340	ENSPREP00000004357	ENSPREP00000034313	Endothelin converting enzyme 2b.	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	0.513
LOC103475295	LOC103472162	ENSPREP00000004357	ENSPREP00000029967	Endothelin converting enzyme 2b.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.681
LOC103475295	LOC103479378	ENSPREP00000004357	ENSPREP00000024191	Endothelin converting enzyme 2b.	Endothelin converting enzyme 2a.	0.525
LOC103475295	agt	ENSPREP00000004357	ENSPREP00000016816	Endothelin converting enzyme 2b.	Angiotensinogen; Belongs to the serpin family.	0.564

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Network Stats

number of nodes:

10

number of edges:

21

average node degree:

4.2

avg. local clustering coefficient:

0.873

expected number of edges:

9

PPI enrichment p-value:

0.000652

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0040019

Positive regulation of embryonic development

2 of 6

2.88

0.81

0.0391

GO:0045039

Protein insertion into mitochondrial inner membrane

2 of 8

2.76

0.8

0.0391

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005743

Mitochondrial inner membrane

4 of 419

1.34

0.72

0.0279

GO:0098798

Mitochondrial protein-containing complex

3 of 267

1.41

0.65

0.0463

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6513

Mixed, incl. Tim10-like, and Mitochondrial intermembrane space import and assembly protein 40

4 of 17

2.73

3.46

5.49e-07

CL:6519

TIM22 mitochondrial import inner membrane insertion complex, and Tim10-like

3 of 5

3.14

2.98

5.61e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

3 of 47

2.16

1.47

0.0019

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 5

2.96

1.46

0.0028

GOCC:0098798

Mitochondrial protein complex

4 of 228

1.6

1.2

0.0028

GOCC:0005740

Mitochondrial envelope

4 of 383

1.38

1.05

0.0034

GOCC:0031967

Organelle envelope

5 of 547

1.32

1.03

0.0028

GOCC:0071013

Catalytic step 2 spliceosome

2 of 37

2.09

0.92

0.0215

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

2 of 20

2.36

1.05

0.0132

KW-0496

Mitochondrion

3 of 160

1.63

0.94

0.0132

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10312

Conserved mid region of cactin

2 of 2

3.36

1.51

0.0023

PF04621

PEA3 subfamily ETS-domain transcription factor N terminal domain

2 of 4

3.06

1.45

0.0029

PF02953

Tim10/DDP family zinc finger

2 of 6

2.88

1.39

0.0036

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019134

Splicing factor Cactin, C-terminal

2 of 2

3.36

1.23

0.0073

IPR018816

Splicing factor cactin, central domain

2 of 2

3.36

1.23

0.0073

IPR006715

PEA3-type ETS-domain transcription factor, N-terminal

2 of 4

3.06

1.22

0.0073

IPR035427

Tim10-like domain superfamily

2 of 6

2.88

1.18

0.0085

IPR004217

Tim10-like

2 of 6

2.88

1.18

0.0085

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01050

Cactus-binding C-terminus of cactin protein

2 of 3

3.18

1.65

0.0013

SM00413

Erythroblast transformation specific domain

2 of 32

2.15

0.8

0.0372

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