fgf5 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

fgf5

Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)

Predicted Functional Partners:

pdgfra

0.833

LOC103469672

0.831

LOC103458160

0.831

LOC103477293

0.831

LOC103473157

0.831

flt4

0.792

LOC103471632

0.792

flt1

0.792

kdr

0.792

csf1r

0.750

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103458160	fgf5	ENSPREP00000009232	ENSPREP00000004455	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.831
LOC103469672	LOC103473157	ENSPREP00000001007	ENSPREP00000019390	Fibroblast growth factor receptor.	Fibroblast growth factor receptor.	0.901
LOC103469672	fgf5	ENSPREP00000001007	ENSPREP00000004455	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.831
LOC103471632	fgf5	ENSPREP00000013540	ENSPREP00000004455	Kinase insert domain receptor like; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.792
LOC103473157	LOC103469672	ENSPREP00000019390	ENSPREP00000001007	Fibroblast growth factor receptor.	Fibroblast growth factor receptor.	0.901
LOC103473157	fgf5	ENSPREP00000019390	ENSPREP00000004455	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.831
LOC103477293	fgf5	ENSPREP00000014037	ENSPREP00000004455	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.831
csf1r	fgf5	ENSPREP00000004302	ENSPREP00000004455	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.750
fgf5	LOC103458160	ENSPREP00000004455	ENSPREP00000009232	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.831
fgf5	LOC103469672	ENSPREP00000004455	ENSPREP00000001007	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.831
fgf5	LOC103471632	ENSPREP00000004455	ENSPREP00000013540	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kinase insert domain receptor like; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.792
fgf5	LOC103473157	ENSPREP00000004455	ENSPREP00000019390	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.831
fgf5	LOC103477293	ENSPREP00000004455	ENSPREP00000014037	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.831
fgf5	csf1r	ENSPREP00000004455	ENSPREP00000004302	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.750
fgf5	flt1	ENSPREP00000004455	ENSPREP00000029019	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.792
fgf5	flt4	ENSPREP00000004455	ENSPREP00000007580	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fms-related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.792
fgf5	kdr	ENSPREP00000004455	ENSPREP00000029186	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.792
fgf5	pdgfra	ENSPREP00000004455	ENSPREP00000028797	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Platelet-derived growth factor receptor, alpha polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.833
flt1	fgf5	ENSPREP00000029019	ENSPREP00000004455	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.792
flt4	fgf5	ENSPREP00000007580	ENSPREP00000004455	Fms-related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.792

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Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.589

expected number of edges:

10

PPI enrichment p-value:

7.05e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000169

Regulation of peptidyl-cysteine S-nitrosylation

4 of 8

3.02

3.79

1.16e-07

GO:0098974

Postsynaptic actin cytoskeleton organization

4 of 15

2.74

3.41

4.54e-07

GO:0060307

Regulation of ventricular cardiac muscle cell membrane repolarization

4 of 15

2.74

3.41

4.54e-07

GO:1901385

Regulation of voltage-gated calcium channel activity

4 of 39

2.33

2.78

4.11e-06

GO:0002027

Regulation of heart rate

4 of 40

2.32

2.77

4.11e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050998

Nitric-oxide synthase binding

4 of 8

3.02

4.04

3.84e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016010

Dystrophin-associated glycoprotein complex

4 of 14

2.77

3.74

1.11e-07

GO:0002102

Podosome

4 of 18

2.66

3.66

1.33e-07

GO:0033017

Sarcoplasmic reticulum membrane

4 of 31

2.43

3.28

4.74e-07

GO:0030175

Filopodium

4 of 72

2.06

2.57

5.11e-06

GO:0030018

Z disc

4 of 102

1.91

2.24

1.61e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:36908

Mixed, incl. Dystrophin-associated glycoprotein complex, and EF hand

7 of 31

2.67

6.88

3.20e-14

CL:36910

EF hand, and Syntrophin

4 of 12

2.84

3.88

6.57e-08

CL:36947

Mixed, incl. Torsin 1/2, and Torsin-1A-interacting protein 1/2

3 of 10

2.79

2.56

1.97e-05

CL:36950

Nitric-oxide synthase binding, and Torsin 1/2

2 of 5

2.92

1.39

0.0031

CL:36912

Mixed, incl. EF hand, and Syntrophin, split Pleckstrin homology (PH) domain

2 of 7

2.77

1.28

0.0047

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000562

Heart

4 of 407

1.31

1.26

0.00028

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016010

Dystrophin-associated glycoprotein complex

5 of 24

2.64

4.6

1.60e-09

GOCC:0045202

Synapse

4 of 531

1.19

0.68

0.0232

GOCC:0016020

Membrane

9 of 5135

0.56

0.38

0.0197

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR015482

Syntrophin

4 of 4

3.32

4.32

1.44e-08

IPR041428

Syntrophin, split Pleckstrin homology (PH) domain

3 of 3

3.32

2.98

4.04e-06

IPR011993

PH-like domain superfamily

7 of 529

1.44

1.83

4.04e-06

IPR006020

PTB/PI domain

3 of 57

2.04

1.28

0.0035

IPR001478

PDZ domain

4 of 201

1.62

1.15

0.0035

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00462

Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain

3 of 39

2.2

1.64

0.00073

SM00233

Pleckstrin homology domain.

4 of 325

1.41

0.99

0.0050

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