Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC103472252ANK_REP_REGION domain-containing protein. (1132 aa)    
Predicted Functional Partners:
LOC103474066
Serine/threonine-protein phosphatase.
    
 0.828
PPP6C
Serine/threonine-protein phosphatase.
    
 0.828
ppp6r2
Protein phosphatase 6, regulatory subunit 2b.
   
 0.714
ppp6r3
Protein phosphatase 6, regulatory subunit 3.
   
 0.714
LOC103459548
Protein phosphatase 6, regulatory subunit 2a.
   
 0.714
usp10
Ubiquitin carboxyl-terminal hydrolase.
   
   0.658
ENSPREP00000027592
Enolase 4.
    
 
 0.514
ap2m1
AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]
    
 0.482
crk
CRK proto-oncogene, adaptor protein.
    
 0.474
ift81
Intraflagellar transport 81 homolog.
    
 0.448
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.