mdm4 protein (Poecilia reticulata) - STRING interaction network

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Score

mdm4

MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (490 aa)

Predicted Functional Partners:

tp53

0.999

mdm2

0.999

atm

0.987

usp7

0.975

csnk1a1

0.937

ywhae

0.935

chek2

0.923

rps27a

0.917

ccng1

0.897

uba52

0.892

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
atm	chek2	ENSPREP00000024388	ENSPREP00000024020	Non-specific serine/threonine protein kinase.	Checkpoint kinase 2.	0.999
atm	mdm2	ENSPREP00000024388	ENSPREP00000032347	Non-specific serine/threonine protein kinase.	MDM2 proto-oncogene.	0.997
atm	mdm4	ENSPREP00000024388	ENSPREP00000004787	Non-specific serine/threonine protein kinase.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.987
atm	rps27a	ENSPREP00000024388	ENSPREP00000018427	Non-specific serine/threonine protein kinase.	Ribosomal protein S27a.	0.934
atm	tp53	ENSPREP00000024388	ENSPREP00000019676	Non-specific serine/threonine protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.999
atm	uba52	ENSPREP00000024388	ENSPREP00000016516	Non-specific serine/threonine protein kinase.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.691
atm	usp7	ENSPREP00000024388	ENSPREP00000028970	Non-specific serine/threonine protein kinase.	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family.	0.512
ccng1	chek2	ENSPREP00000007663	ENSPREP00000024020	CYCLIN domain-containing protein; Belongs to the cyclin family.	Checkpoint kinase 2.	0.437
ccng1	mdm2	ENSPREP00000007663	ENSPREP00000032347	CYCLIN domain-containing protein; Belongs to the cyclin family.	MDM2 proto-oncogene.	0.968
ccng1	mdm4	ENSPREP00000007663	ENSPREP00000004787	CYCLIN domain-containing protein; Belongs to the cyclin family.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.897
ccng1	rps27a	ENSPREP00000007663	ENSPREP00000018427	CYCLIN domain-containing protein; Belongs to the cyclin family.	Ribosomal protein S27a.	0.425
ccng1	tp53	ENSPREP00000007663	ENSPREP00000019676	CYCLIN domain-containing protein; Belongs to the cyclin family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.955
ccng1	uba52	ENSPREP00000007663	ENSPREP00000016516	CYCLIN domain-containing protein; Belongs to the cyclin family.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.583
chek2	atm	ENSPREP00000024020	ENSPREP00000024388	Checkpoint kinase 2.	Non-specific serine/threonine protein kinase.	0.999
chek2	ccng1	ENSPREP00000024020	ENSPREP00000007663	Checkpoint kinase 2.	CYCLIN domain-containing protein; Belongs to the cyclin family.	0.437
chek2	mdm2	ENSPREP00000024020	ENSPREP00000032347	Checkpoint kinase 2.	MDM2 proto-oncogene.	0.987
chek2	mdm4	ENSPREP00000024020	ENSPREP00000004787	Checkpoint kinase 2.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.923
chek2	rps27a	ENSPREP00000024020	ENSPREP00000018427	Checkpoint kinase 2.	Ribosomal protein S27a.	0.633
chek2	tp53	ENSPREP00000024020	ENSPREP00000019676	Checkpoint kinase 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.999
chek2	uba52	ENSPREP00000024020	ENSPREP00000016516	Checkpoint kinase 2.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.431